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ProteomicsIn Situ Cross-linking Based Co-Fractionation Mass Spectrometry (XL-CoFrac-MS)
We developed an in situ cross-linking coupled reversed-phase liquid chromatography-based co-fractionation mass spectrometry (XL-CoFrac-MS) platform to analyze drug-induced protein complex changes. A software tool, ChromaQuant, was built to automate chromatographic peak quantification. Using RS4;11 l...
ORGANISM(S): Homo Sapiens 
PXD067673 |
ProteomicsQuantative pTyr protein complex
Our current research focuses on the complex-centric quantification of pTyr protein complexes. We initially constructed a tri-functional probe based on pTyr superbinder (SH2-S) for the enrichment of pTyr protein complexes. The pTyr protein complexes were separated by ion exchange chromatography (IEC)...
ORGANISM(S): Homo Sapiens 
PXD052742 |
ProteomicsBacterial community structure and metabolomic pathways in yak milk and cattle-yak milk during refrigeration: analysis of interspecific differences in dairy spoilage
Raw milk usually needs to be refrigerated at 4℃ before production, and microbial contamination during this process can cause spoilage of refrigerated raw milk. However, there is currently almost no research on plateau characteristic milk (yak milk and cattle-yak milk) (YM and CYM). In this study, si...
ORGANISM(S): Bos Taurus 
2024-03-22 | PXD050886 |
ProteomicsComparative proteomic analysis of two divergent Lingzhi strains
It is reported that heat stress could induce the biosynthesis of ganoderic acids and enhance the production of G. lingzhi polysaccharides. However, heat stress inhibits mycelium growth and reduces hyphal branching, resulting in a significant reduction in mycelial dry weight. Tandem mass tag-based (T...
ORGANISM(S): Ganoderma Lingzhi 
2022-06-15 | PXD034524 |
ProteomicsBRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK
Erythropoiesis is a crucial part in hematopoietic system, while facing disruptions from various diseases conditions. Anemia and blood shortages has become global challenges, with current finite pharmacological options like EPO or glucocorticoids having limitations, especially in genetic anemias like...
ORGANISM(S): Homo Sapiens 
PXD055730 |
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