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ProteomicsImmunotherapeutic antibodies derived from human tumor tertiary lymphoid structures
We report that intratumoral Tertiary Lymphoid Structures (TLS) in human ovarian cancer contain highly oligoclonal B cells that produce IgA and IgG. Using a recombinant antibody cloned from the dominant sequence of an ovarian cancer TLS, we abrogated the growth of the autologous human tumor in vivo, ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-12 | PXD036740 | Pride
Ovarian cancer Target identification Antibodies Tertiary lymphoid structures 
UnknownDesigning a Person-Centred Integrated Care Programme for People with Complex Chronic Conditions: A Case Study from Catalonia.
Not available
S-EPMC8622001 | biostudies-literature
UnknownA chimeric Mla-Pqi lipid transport system is required for Brucella abortus survival in macrophages
Not available
S-SCDT-10_1038-S44318-025-00511-3 | biostudies-other
ProteomicsSirt2 inhibition reprograms T cell metabolism for optimal anti-tumor immunity: Sirt2 Interacting Proteins
Growing evidence indicates that metabolism is a key driver of T cell functions. A switch from oxidative phosphorylation to aerobic glycolysis is a hallmark of T cell activation and is required to meet metabolic demands of proliferation and effector functions. However, the mechanisms underlying the m...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-15 | PXD012811 | Pride
T cell Sirtuin 2 Metabolism Interacting proteins Glycolysis 
ProteomicsSirt2 inhibition reprograms T cell metabolism for optimal anti-tumor immunity: Lysine Acetylation
Growing evidence indicates that metabolism is a key driver of T cell functions. A switch from oxidative phosphorylation to aerobic glycolysis is a hallmark of T cell activation and is required to meet metabolic demands of proliferation and effector functions. However, the mechanisms underlying the m...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-15 | PXD012796 | Pride
T cell Sirtuin 2 Metabolism Acetylation Glycolysis 
ProteomicsSirt2 inhibition reprograms T cell metabolism for optimal anti-tumor immunity: Sirt2 Interacting Proteins 2
Growing evidence indicates that metabolism is a key driver of T cell functions. A switch from oxidative phosphorylation to aerobic glycolysis is a hallmark of T cell activation and is required to meet metabolic demands of proliferation and effector functions. However, the mechanisms underlying the m...
ORGANISM(S): Mus musculus (Mouse) 
2020-07-03 | PXD020150 | Pride
T cell Sirtuin 2 Metabolism Interacting proteins Glycolysis 
MetabolomicsDeep insights into microsampling technologies for global lipidomic profiling of human whole blood using high-throughput LC-MS

In recent years, blood microsampling (BμS) technologies have gained popularity, as they offer simplicity, minimal invasiveness, and suitability for remote sample collection. In this study, the aim was to explore the potential of three BμS devices for reliable untargeted lipidomic profiling using ...

2025-09-30 | MTBLS10722 | MetaboLights
UnknownOral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12).
Not available
S-EPMC3403849 | biostudies-literature
UnknownThe RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate.
Not available
S-EPMC10234631 | biostudies-literature
UnknownAnti-4-1BB immunotherapy enhances systemic immune effects of radiotherapy to induce B and T cell-dependent anti-tumor immune activation and improve tumor control at unirradiated sites.
Not available
S-EPMC10992043 | biostudies-literature
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