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ProteomicsPreferential phosphorylation on old histones during early mitosis in human cells
How histone posttranslational modifications (PTMs) are inherited through cell cycle remains poorly understood. Canonical histones are made in the S phase of cell cycle. Combining mass spectrometry-based technologies and stable isotope labeling by amino acids in cell culture (SILAC), we interrogate t...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD003709 | Pride
Mass spectrometry Mitosis Histone modifications Cell cycle Histone phosphorylation 
ProteomicsChromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
Schizophrenia (SZ) is a psychiatric disorder with complex genetic risk dictated by interactions between hundreds of risk variants. Epigenetic factors, such as histone posttranslational modifications (PTMs), have been shown to play critical roles in many neurodevelopmental processes, and when perturb...
ORGANISM(S): Homo sapiens (Human) 
2022-05-06 | PXD031767 | Pride
Bet proteins Mass spectrometry Histone modifications Schizophrenia Rna-seq 
TranscriptomicsDual Mechanisms by which MiR-125b Represses IRF4 to Induce Myeloid and B cell Leukemias
The oncomir microRNA-125b (miR-125b) is up-regulated in a variety of human neoplastic blood disorders and constitutive up-regulation of miR-125b in mice can promote myeloid and B cell leukemia. We found that miR-125b promotes myeloid and B cell neoplasm by inducing tumorigenesis in hematopoietic pro...
ORGANISM(S): Mus musculus 
2014-06-27 | E-GEOD-58900 | biostudies-arrayexpress
ProteomicsHistione HCD and CID datasets for evaluation of search engines
To identify confident spectra from histone peptides containing PTMs, we present a method in which one kind of modification is searched each time. We then combine the identifications of multiple search engines to obtain confident results. We find that two search engines, pFind and Mascot, identify mo...
ORGANISM(S): Homo sapiens (Human) 
2014-09-01 | PXD001118 | Pride
Proteomics Search engine Post-translational modification Data analysis Histone 
ProteomicsEpiProfile 2.0: a proteomics tool to quantify histone modifications by mass spectrometry
The histone LC-MS/MS data analysis is challenging due to the large number and variety of isobaric histone peptides, and the high dynamic range of histone peptide abundances. We introduce EpiProfile 2.0 to quantify histone post-translational modifications from mass spectrometry data, in which fragmen...
ORGANISM(S): Homo sapiens (Human) 
2018-05-29 | PXD004166 | Pride
Proteomics Post-translational modification Mass spectrometry Histone Quantification 
ProteomicsQuantifying histone PTMs by bottom-up MS
Histone post-translational modifications (PTMs) contribute to chromatin function through their chemical properties which influence chromatin structure, and their ability to recruit chromatin interacting proteins. Nanoflow liquid chromatography coupled with high resolution tandem mass spectrometry (n...
ORGANISM(S): Homo sapiens (Human) 
2015-03-27 | PXD001541 | Pride
Proteomics Post-translational modification Isobaric peptide Retention time Histone Quantification 
ProteomicsQuantitative profiling of the enzymatic activity of the protein lysine mono-methyltransferase SMYD2 using SILAC-based proteomics
The significance of non-histone lysine methylation in cell biology and human disease is an emerging area of research exploration, and small molecule inhibitors that selectively and potently target “writers” and “erasers” of methyl-lysine, such as the protein lysine mono-methyltransferase SMYD2, are ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080785 | MassIVE
ProteomicsIntegrated Multi-Omics Reveal Polycomb Repressive Complex 2 Restricts Human Trophoblast Induction
Human naive pluripotent stem cells have unrestricted lineage potential. Underpinning this property, naive cells are thought to lack chromatin-based lineage barriers. However, this assumption has not been tested. Here, we define the chromatin-associated proteome, histone post-translational modificati...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD032792 | Pride
H3k27me3 Trophoblast fate Polycomb repressive complex 2 (prc2) Chromatin proteomes Human pluripotent stem cells 
ProteomicsQuantitative proteomics analysis of histone modifications from NSD2 inhibitor treated lung and pancreatic cancer cell lines.
Quantitative mass spectrometry(qMS)-based epigenetic profiling of the indicated histone modifications from cells treated NSD2 inhibitor.
ORGANISM(S): Homo sapiens (Human) 
2025-04-14 | PXD059343 | Pride
Cancer Histone modification 
ProteomicsTwo DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastids
In higher eukaryotes, a single DOT1 histone H3 lysine 79 (H3K79) methyltransferase processively produces H3K79me2/me3 from me0 through histone H2B mono-ubiquitin interaction. The early-branched kinetoplastid Trypanosoma brucei harbors the essential H3K76 di-methyltransferase DOT1A and the non-essent...
ORGANISM(S): Trypanosoma Brucei (ncbitaxon:5691) 
2022-11-09 | MSV000090680 | MassIVE
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