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TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76743 | biostudies-arrayexpress
TranscriptomicsDeletion of UTX, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome.
Kabuki syndrome (KS) is a rare multiple congenital anomalies/mental retardation (MCA/MR) syndrome described in 19811,2. In 2010, exome sequencing identified MLL2 mutations in patients with KS3. Since then, 5 studies identified a mutation in MLL2 in 56-75,6% of KS patients3-7. Here, we describe 2 ...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-32567 | biostudies-arrayexpress
TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia I.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76741 | biostudies-arrayexpress
UnknownRandomized multicenter phase II trial comparing two schedules of etirinotecan pegol (NKTR-102) in women with recurrent platinum-resistant/refractory epithelial ovarian cancer.
Not available
S-EPMC4878105 | biostudies-literature
ProteomicsProximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia.
Microglia are resident immune cells of the brain and regulate its inflammatory state. In neurodegenerative diseases, microglia transition from a homeostatic state to a state referred to as disease associated microglia (DAM). DAM express higher levels of proinflammatory signaling molecules, like STAT...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-05-06 | PXD049433 | Pride
Proximity labeling Neurodegeneration Neuroinflammation Kv1.3 potassium channel Microglia 
UnknownThe abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy.
Not available
S-EPMC10087690 | biostudies-literature
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [CGH]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-40966 | biostudies-arrayexpress
TranscriptomicsImplication of Long noncoding RNAs in the endothelial cell response to hypoxia II.
Long noncoding RNAs (lncRNAs) are non-protein coding RNAs regulating gene expression. Although for some lncRNAs a relevant role in hypoxic endothelium has been shown, the regulation and function of lncRNAs is still largely unknown in the vascular physio-pathology. Taking advantage of next-generation...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-76739 | biostudies-arrayexpress
ProteomicsA combined N-terminomics and shotgun proteomics approach to investigate the responses of human cells to rapamycin and zinc at the mitochondrial level
This study aims at investigating the impact of rapamycin and zinc at subtoxic doses on the human mitochondrial proteome. Experiments were performed on U397 monocytic cells. A dN-TOP strategy, combining shotgun proteomics and N-terminomics, was applied to study both internal and N-terminal peptides o...
ORGANISM(S): Homo sapiens (Human) 
2019-05-14 | PXD010220 | Pride
N-terminome analysis Mitochondria Nanolc-ms/ms Dn-top strategy Differential analysis 
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