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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsHuman ES cells reveal recurrent genomic instability at 20q11.21
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we detected a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing about 23 genes in common, appeared in four cell lines of different origins. This amplification, ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-13565 | biostudies-arrayexpress
TranscriptomicsGenome-wide array comparative genomic hybridization (aCGH) profiling of endothelial progenitor cells, and their comparison to tumor plasma cells, in multiple myeloma
In multiple myeloma (MM), endothelial progenitor cells (EPCs) regulate tumor angiogenesis and disease progression. EPCs from 16 newly diagnosed patients with advanced MM were examined for genomic instability by aCGH to assess chromosomal gains and losses. Data were compared to aCGH results from corr...
ORGANISM(S): Homo sapiens 
2011-04-02 | E-GEOD-28329 | biostudies-arrayexpress
TranscriptomicsLeishmania donovani amastigotes: Nelfinavir (NFV)-sensitive (control) vs Nelfinavir-resistant [Comparative Genomic Hybridization (DNA) profiling]
Drug resistance is a major public health challenge in Leishmaniasis chemotherapy, particularly in the case of emerging Leishmania/HIV-1 co-infections. Recently, we have delineated the mechanism of cell death induced by the HIV-1 protease inhibitor, Nelfinavir, in the Leishmania parasite. In order to...
ORGANISM(S): Leishmania donovani 
2013-06-27 | E-GEOD-42195 | biostudies-arrayexpress
UnknownEffectiveness of a Novel ω-3 Krill Oil Agent in Patients With Severe Hypertriglyceridemia: A Randomized Clinical Trial.
Not available
S-EPMC8739762 | biostudies-literature
TranscriptomicsRecurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells
array-CGH analysis of human neural stem cells derived from human ES cells during long term in vitro culture array-CGH analysis of human neural stem cells derived from human ES cells comparing control genomic DNA
ORGANISM(S): Homo sapiens 
2012-01-25 | E-GEOD-33708 | biostudies-arrayexpress
UnknownNKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.
Not available
S-EPMC9479122 | biostudies-literature
UnknownTrends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021.
Not available
S-EPMC11330450 | biostudies-literature
UnknownGain-of-function lipoprotein lipase variant rs13702 modulates lipid traits through disruption of a microRNA-410 seed site.
Not available
S-EPMC3542456 | biostudies-literature
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