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MetabolomicsStage-specific roles of microbial dysbiosis and metabolic disorders in rheumatoid arthritis

OBJECTIVE: Rheumatoid arthritis (RA) is a progressive disease including four stages, where gut microbiome is associated with pathogenesis. We aimed to investigate stage-specific roles of microbial dysbiosis and metabolic disorders in RA.

METHODS: We investi...

2023-01-31 | MTBLS5297 | MetaboLights
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
UnknownUndifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation.
Not available
S-EPMC6593872 | biostudies-literature
Unknownβ-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.
Not available
S-EPMC8533582 | biostudies-literature
Transcriptomicsrlm1 mutant 3 hour exposure to zymolyase
We did transcription profiling on the effect of rlm1 deletion, gene involved in cell wall stress response Keywords: cell wall stress response S. cerevisiae (rlm1 mutant) was grown on YEPD. For Zymolyase experiments, yeast cells were grown overnight at 24 °C to an optical density 0.8 - 1 (A600). The...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-19 | E-GEOD-9933 | biostudies-arrayexpress
Transcriptomicsslt2 mutant 3 hour exposure to zymolyase
We did transcription profiling on the effect of slt2 deletion, gene involved in cell wall stress response Keywords: cell wall stress response S. cerevisiae (slt2 mutant) was grown on YEPD. For Zymolyase experiments, yeast cells were grown overnight at 24 °C to an optical density 0.8 - 1 (A600). The...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-19 | E-GEOD-9932 | biostudies-arrayexpress
Transcriptomicsmsn2/4 mutant 3 hour exposure to zymolyase
We did transcription profiling on the effect of msn2 msn4 deletion, genes involved in several stress process Keywords: cell wall stress response S. cerevisiae (msn2/4 mutant) was grown on YEPD. For Zymolyase experiments, yeast cells were grown overnight at 24 °C to an optical density 0.8 - 1 (A600)...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-19 | E-GEOD-9934 | biostudies-arrayexpress
Transcriptomicshog1 mutant 3 hour exposure to zymolyase
We did transcription profiling on the effect of hog1 deletion, gene involved in cell osmotic stress and cell wall stress response Keywords: cell wall stress response S. cerevisiae (hog1 mutant) was grown on YEPD. For Zymolyase experiments, yeast cells were grown overnight at 24 °C to an optical den...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-19 | E-GEOD-9931 | biostudies-arrayexpress
ProteomicsDimeric IgA specifically disables intracellular mutated oncodrivers
Despite their long half-life, therapeutic antibodies are considered ineffective against intracellular antigens due to their perceived inability to penetrate epithelial cells. Using recombinant antibodies targeting common mutations in oncogenes, we show that dimeric IgA, but not the same antibody on ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD042914 | Pride
Transcytosis Cancer Therapeutic antibodies Immunoglobulin a 
UnknownPeriprocedural Direct Oral Anticoagulant Management: The RA-ACOD Prospective, Multicenter Real-World Registry.
Not available
S-EPMC7319799 | biostudies-literature
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