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TranscriptomicsA Novel Tumor suppressor network in squamous malignancies
The specific ablation of Rb1 gene in stratified epithelia (RbF/F;K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues, however RbF/F;K14cre;p107-/- mice die post...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-38257 | biostudies-arrayexpress
TranscriptomicsAkt signalling leads to stem cell activation and promotes tumour development in epidermis.
A permantly active form of the oncogene Akt was expressed in the keratinocytes of the basal proliferative layer of the epidermis. Stem cells of the hair follicle expressing the cell surface marker CD34 were isolated. RNA form the CD34(+) and CD34(-) keratinocytes was extracted and and hybridized to ...
ORGANISM(S): Mus musculus 
2014-01-26 | E-GEOD-48522 | biostudies-arrayexpress
UnknownA Phase I/IIa Prospective, Randomized, Open-Label Study on the Safety and Efficacy of Nebulized Liposomal Amphotericin for Invasive Pulmonary Aspergillosis.
Not available
S-EPMC10970827 | biostudies-literature
TranscriptomicsE2F1 loss induces spontaneous tumour development in Rb-deficient epidermis
The specific ablation of Rb1 gene in epidermis (RbF/F;K14cre) promotes proliferation and altered differentiation but does not produce spontaneous tumour development. These phenotypic changes are associated with increased expression of E2F members and E2F-dependent transcriptional activity. Here, we ...
ORGANISM(S): Mus musculus 
2012-08-20 | E-GEOD-38048 | biostudies-arrayexpress
TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
TranscriptomicsSingle cell sequencing analysis of senescence in Mus musculus prostate cancer models
Acute Pten loss initiates prostate tumorigenesis characterized by cellular senescence response. Here we examine the cellular senescence response in epithelial individual cells, by single-cell RNA sequencing (scRNAseq) in Ptenpc-/- and Ptenpc-/-; Timp1-/- GEMMs. ScRNAseq analysis determines a cluste...
ORGANISM(S): Mus musculus 
2020-10-09 | E-MTAB-9578 | biostudies-arrayexpress
UnknownSeventeen-year reassessment of diagnostic transitions, biologic therapy initiation and mortality in spondyloarthritis: results from the REGISPON-3 study.
Not available
S-EPMC12506471 | biostudies-literature
TranscriptomicsRNA seq of prostate gland from WT, PTEN pc -/- and PTEN pc-/-;P53 -/- mice
Acute Pten loss initiates prostate tumorigenesis characterized by cellular senescence response. Senescent cells secrete a variety of pro inflammatory factors in the tumor microenvironment, which can support the survival, outgrowth and migration of tumor cells. Here we examine cytokines and cytokines...
ORGANISM(S): Mus musculus 
2020-10-09 | E-MTAB-9624 | biostudies-arrayexpress
UnknownTumour location and efficacy of first-line EGFR inhibitors in KRAS/RAS wild-type metastatic colorectal cancer: retrospective analyses of two phase II randomised Spanish TTD trials.
Not available
S-EPMC6890384 | biostudies-literature
UnknownDalbavancin as Suppressive Therapy for Implant-Associated Osteoarticular Infections.
Not available
S-EPMC12649215 | biostudies-literature
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