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TranscriptomicsGene Regulatory Circuitry of JNK Signaling Identifies Novel Regulators of Epithelial to Mesenchymal Transition
Purpose: The purpose of this study is to investigate role of JNK signaling during EMT. Method: Transcriptome of TGF-b treated NmuMG cells along with DMSO and JNKi treated NMuMG was generated using next generation high throughput sequencing in triplicates and duplicates respectively. Reads were mappe...
ORGANISM(S): Mus musculus 
2015-07-13 | E-GEOD-54133 | biostudies-arrayexpress
TranscriptomicsThe transcriptome of central nervous system myelin
Rapid nerve conduction in the CNS is facilitated by the insulation of axons with myelin, a specialized oligodendroglial compartment distant from the cell body. Myelin is turned over and adapted throughout life; however, the molecular and cellular basis of myelin dynamics is not well understood. Hypo...
ORGANISM(S): Mus musculus 
2016-06-24 | E-GEOD-78151 | biostudies-arrayexpress
GenomicsDynamics and Function of Distal Regulatory Elements during Neurogenesis and Neuroplasticity
Gene regulation in mammals involves a complex interplay between promoter and distal regulatory elements that function in concert to drive precise spatio-temporal gene expression programs. However, the dynamics of distal gene regulatory elements and its function in transcriptional reprogramming that ...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-65713 | biostudies-arrayexpress
TranscriptomicsGene regulation and priming by Topoisomerase IIα in embryonic stem cells [RNA-Seq]
Topoisomerases are essential for resolving topological problems in the genome, while their function in gene regulation, especially during cellular differentiation, remains unknown. We reveal that the expression of two Topo II isoforms, Top2a and Top2ß, is characteristic of dividing and postmitotic t...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-46066 | biostudies-arrayexpress
GenomicsGene regulation and priming by Topoisomerase II? in embryonic stem cells [FAIRE-Seq]
Topoisomerases are essential for resolving topological problems in the genome, while their function in gene regulation, especially during cellular differentiation, remains unknown. We reveal that the expression of two Topo II isoforms, Top2a and Top2ß, is characteristic of dividing and postmitotic t...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-49141 | biostudies-arrayexpress
TranscriptomicsGene regulation and priming by Topoisomerase IIα in embryonic stem cells [ChIP-chip]
Topoisomerases are essential for resolving topological problems in the genome, while their function in gene regulation, especially during cellular differentiation, remains elusive/unknown. We reveal that the expression of two Topo II isoforms, Top2α and Top2β, is characteristic of dividing and pos...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-45890 | biostudies-arrayexpress
TranscriptomicslncRNAs at 13q14.3
Investigation of the upregulation of lncRNA genes in 13q14.3 and ist correlation with downregulation in cis of a gene cluster regulating NF-kB
ORGANISM(S): Homo sapiens 
2015-06-30 | E-MTAB-1335 | biostudies-arrayexpress
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