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TranscriptomicsMicroRNA expression profiling analysis on a group of 52 heredo-familial and sporadic breast cancer samples
In this study, using microarray technology we did a transcriptome profiling of miRNAs on a group of 52 cases of familial (BRCA1- or BRCA2-mutated, or BRCAX, i.e. familial cases with no mutations in BRCA1 or BRCA2 genes) and sporadic breast cancers. Class comparison of different clinical characterist...
ORGANISM(S): Homo sapiens 
2014-05-14 | E-GEOD-46966 | biostudies-arrayexpress
TranscriptomicsGermline whole-exome sequencing in non smoker lung cancer patients to identify predisposing alterations
Molecular characterization of genomic alterations occurring in two distinct cohorts of 75 never-smoker lung adenocarcinoma (NSCLC) patients .Aim of the study is the identification of molecular alterations involving an increased risk of developing a lung cancer. First group of 32 cases (cohort 1, C1)...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-14468 | biostudies-arrayexpress
TranscriptomicsGermline whole-exome sequencing in non smoker lung cancer patients to identify predisposing alterations
Molecular characterization of genomic alterations occurring in two distinct cohorts of 75 never-smoker lung adenocarcinoma (NSCLC) patients .Aim of the study is the identification of molecular alterations involving an increased risk of developing a lung cancer. Second group of 60 cases (cohort 2, C2...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-14520 | biostudies-arrayexpress
TranscriptomicsIntegrative approach for prioritizing cancer genes in sporadic colon cancer
The current multistep carcinogenesis models of colon cancer do not fully capture the genetic heterogeneity of the disease, which is additionally complicated by the presence of passenger and driver genetic alterations. The aim of the present study was to select in the context of this significant hete...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-16125 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation
Abstract: Altered expression of microRNAs (miRNAs) is associated with development and progression of various human cancers by regulating the translation of oncogenes and tumor suppressor genes. In colorectal cancer (CRC), these regulators complement the Vogelstein multi-step model of pathogenesis an...
ORGANISM(S): Homo sapiens 
2012-02-22 | E-GEOD-28364 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human thyrocytes stably expressing wild type RET/PTC1 oncogene or RET/PTC1 carrying Y451F mutation and parental thyrocytes
Mass populations of thyrocytes stably expressing wild type RET/PTC1 oncogene or RET/PTC1 carrying Y451F mutation and parental thyrocytes were used for hybridization on Affymetrix HG-U133A and HG-U133B chips. For each cell condition were generated two different targets (indicated as two different sam...
ORGANISM(S): Homo sapiens 
2005-09-30 | E-MEXP-429 | biostudies-arrayexpress
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