Sort   by:  
 Page size 
ProteomicsOpposing effects of cancer-type-specific SPOP mutations on BET protein degradation and sensitivity to BET inhibitors
Janouskova H, El Tekle G, Bellini E, Udeshi ND, Rinaldi A, Ulbricht A, Bernasocchi T, Civenni G, Losa M, Svinkina T, Bielski CM, Kryukov GV, Cascione L, Sara Napoli S, Enchev RI, Mutch DG, Carney ME, Berchuck A, Winterhoff BJN, Broaddus RR, Schraml P, Moch H, Bertoni F, Catapano CV, Peter M, Carr SA...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-12-16 | MSV000080401 | MassIVE
TranscriptomicsExpression data from melanoma xenograft tumors originating from primary immortalized melanocytes
PREX2 truncating mutations occur in melanoma. We used microarray based gene expression profiling to compare expression patterns between xenografts harboring control GFP, wt PREX2 or various human relevant PREX2 mutants Primary xenograft tumors derived from primary immortalized melanocytes expressing...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-57309 | biostudies-arrayexpress
TranscriptomicsExpression data from Suv420h1 knockout and mutant PREX2 expressing MEFs (mouse embryonic fibroblasts)
PREX2 truncating mutations occur in melanoma. We used microarray based gene expression profiling to compare expression patterns between cells harboring Suv420h1 knockout and PREX2 mutant expressing Spontaneously immortalized MEFs from either wt or Suv420h1 knockout mice were used. Wt MEFs were trans...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-57310 | biostudies-arrayexpress
TranscriptomicsAberrant ERK signaling causes resistance to EGFR kinase inhibitors
The clinical efficacy of EGFR kinase inhibitors is limited by the development of drug resistance. The irreversible EGFR kinase inhibitor WZ4002 is effective against the most common mechanism of drug resistance mediated by the EGFR T790M mutation. Here we show that in multiple complementary models ha...
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-37699 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of xenografts and mouse embryonic fibroblasts with ectopically expressed PREX2 mutants
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-57311 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics of the Cancer Cell Line Encyclopedia
The Cancer Cell Line Encyclopedia (CCLE) is a collaborative effort to generate steady-state large-scale profiling across a collection of nearly a thousand cancer cell lines. Multiple generations of this effort have resulted in a collection of many data types such as RNA expression, mutation annotati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-27 | MSV000085836 | MassIVE
TranscriptomicsExpression analysis of human melanoma short-term culture WM451-Lu harvested after lentiviral infection with a GFP (control) or SETDB1 (experimental) viral vector
Investigation of expression differences induced by expression of the histone methyltransferase SETDB1 in human melanoma short-term culture WM451-Lu. A six-chip study using total RNA prepared from WM451-Lu melanoma short-term cultures infected with either a lentivirus encoding GFP (control) or SETDB1...
ORGANISM(S): Homo sapiens 
2011-01-07 | E-GEOD-26371 | biostudies-arrayexpress
GenomicsEpigenomic alterations in localized and advanced prostate cancer
Here we used Illumina NGS for high-throughput profiling of the DNA methylome in seven human benign prostate tissues, seven human primary prostate cancer and six human castration resistant prostate cancer patient samples. These data were used to profile the CpG cytosine methylation pattern at single ...
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-41701 | biostudies-arrayexpress
UnknownExpression analysis of human melanoma short-term culture WM451-Lu harvested after lentiviral infection with a GFP (control) or SETDB1 (experimental) viral vector
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-26371 | biostudies-other
TranscriptomicsMelanoma short-term cultures and cell lines: expression profiling and CNV analyses
This SuperSeries is composed of the following subset Series: GSE17349: Expression data for melanoma short-term cultures and cell lines GSE17359: Affymetrix SNP array data for 3 melanoma short-term cultures and cell lines GSE20156: RNA-Seq of melanoma short-term cultures and cell lines Refer to indiv...
ORGANISM(S): Homo sapiens 
2010-02-01 | E-GEOD-17593 | biostudies-arrayexpress
Sort   by:  
 Page size