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TranscriptomicsGene expression signature overlap between shETV1 and BRD32048 in LNCaP and SK-MEL-28
Identification of BRD32048 as an inhibitor of ETV1 oncogenic transcription factor. This compound was indentified by small molecule mcroarray (a binding assay). It was able to consistently inhibit an ETV1-dependent MMP1-driven luciferase signal. Its direct binding was validated by Suface plasmon reso...
ORGANISM(S): Homo sapiens 
2013-11-07 | E-GEOD-52154 | biostudies-arrayexpress
TranscriptomicsNuclear Factor I/B is an Oncogene in Small Cell Lung Cancer
Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed only after it has metastasized to distant sites (Meuwissen and Berns 2005; Cooper and Spiro 2006). Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels (Forgacs ...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29533 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics of the Cancer Cell Line Encyclopedia
The Cancer Cell Line Encyclopedia (CCLE) is a collaborative effort to generate steady-state large-scale profiling across a collection of nearly a thousand cancer cell lines. Multiple generations of this effort have resulted in a collection of many data types such as RNA expression, mutation annotati...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-07-27 | MSV000085836 | MassIVE
GenomicsPCGP Histone-Capture bams - samples
DATA FILES FOR Histone Capture bams
EGAD00001000657 | EGA
GenomicsThe landscape of somatic mutations in epigenetic regulators across 1000 pediatric cancer genomes
To define the frequency and pattern of somatic mutations in epigenetic regulators in pediatric cancer, we sequenced 633 genes, encoding the majority of proteins involved in patterning the epigenome, in 1000 pediatric tumors spanning 21 different cancer subtypes. This analysis establishes an epigenet...
EGAS00001000449 | EGA
GenomicsProstate Cancer Genome Sequencing Project

Prostate cancer is a prevalent cause of cancer morbidity and mortality in men. In order to characterize the full range of somatic mutations in protein-coding genes that may drive the growth of prostate cancer, we sequenced the exonic regions of genomic and tumor DNA from over 100 patients with hi...

phs000447.v1.p1 | EGA
TranscriptomicsAn Integrated Approach to Uncover Drivers of Cancer
We developed a computational framework that integrates chromosomal copy number and gene expression data for detecting aberrations that promote cancer progression. We demonstrate the utility of this framework using a melanoma dataset. Our analysis correctly identified known drivers of melanoma and pr...
ORGANISM(S): Homo sapiens 
2010-12-01 | E-GEOD-23884 | biostudies-arrayexpress
GenomicsThe Genomic Complexity of Primary Human Prostate Cancer

Seven primary prostate cancers and their paired normal counterparts were DNA-sequenced on a massively parallel sequencing platform. This approach was taken to investigate the genomes for mutations and genomic alterations that would be undetectable by lower-resolution methods. As result, tumor...

phs000330.v1.p1 | EGA
GenomicsWhole Genomic Sequencing of Nine Primary Colorectal Adenocarcinoma Tumor/Germline Pairs

This study was the first-known effort to complete the complete genome sequencing of primary colorectal adenocarcinomas and the matched germline genome. Nine colorectal adenocarcinomas selected on the basis of having chromosomal instability were subjected to 'shotgun' Illumina sequencing w...

phs000374.v1.p1 | EGA
GenomicsMelanoma Genome Sequencing Project

Melanoma is the most prevalent cause of skin cancer morbidity and mortality. In order to characterize the full range of somatic mutations that may drive the growth of melanoma, we are sequencing tumor and normal DNA from a set of roughly 150 melanomas. For the majority of samples (approximately 9...

phs000452.v1.p1 | EGA
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