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TranscriptomicsTranscription profiling of Dahl salt-sensitive and salt-resistant congenic rats
Kidney samples from three Dahl Salt-sensitive S rats were compared with kidney samples from three S.R(9)x3A congenic rats.
ORGANISM(S): Rattus norvegicus 
2007-09-13 | E-GEOD-1775 | biostudies-arrayexpress
GenomicsMutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-Seq]
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms including disabling pro-apoptotic proteins and by regulating gene expression. Analysis of promoter regions identified through CHIP-on-CHIP and CHIP-SEQ platforms reveal that the ETS motif (EBS) is prevalent within predic...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36749 | biostudies-arrayexpress
TranscriptomicsMutant p53 cooperates with ETS2 to promote etoposide resistance [ChIP-chip]
Mutant p53 (mtp53) promotes chemotherapy resistance through multiple mechanisms including disabling pro-apoptotic proteins and by regulating gene expression. Analysis of promoter regions identified through CHIP-on-CHIP and CHIP-SEQ platforms reveal that the ETS motif (EBS) is prevalent within predic...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-36751 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling with a Blood Pressure QTL interval-specific oligonucleotide array
Although the evidence for a genetic predisposition to human essential hypertension is compelling, the genetic control of blood pressure (BP) is poorly understood. The Dahl salt-sensitive (S) rat is a model for studying the genetic component of BP. Using this model we previously reported the identif...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-1622 | biostudies-arrayexpress
TranscriptomicsAT13148 is a novel, oral multi-AGC kinase inhibitor with potent pharmacodynamic and antitumor activity
Purpose: Deregulated phosphatidylinositol 3-kinase pathway signaling through AGC kinases including AKT, p70S6 kinase, PKA, SGK and Rho kinase, is a key driver of multiple cancers. The simultaneous inhibition of multiple AGC kinases may increase antitumor activity and minimize clinical resistance com...
ORGANISM(S): Homo sapiens 
2012-07-19 | E-GEOD-38008 | biostudies-arrayexpress
UnknownIdentification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.
Not available
S-EPMC9857322 | biostudies-literature
UnknownWHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.
Not available
S-EPMC10473809 | biostudies-literature
UnknownWhole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.
Not available
S-EPMC11992084 | biostudies-literature
UnknownEnhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information.
Not available
S-EPMC8917986 | biostudies-literature
UnknownIdentification of six new susceptibility loci for invasive epithelial ovarian cancer.
Not available
S-EPMC4445140 | biostudies-literature
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