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MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
TranscriptomicsSynergistic Tumor Suppressor Activity of E-cadherin and p53 in a Conditional Mouse Model for Diffuse-Type Gastric Cancer
BACKGROUND & AIMS: Gastric cancer is the second most frequent cause of death from cancer in the world, diffuse-type gastric cancer (DGC) exhibiting a poor prognosis. Germline mutations of CDH1, encoding E-cadherin, have been reported in hereditary DGCs, and genetic and/or epigenetic alterations of C...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-25302 | biostudies-arrayexpress
TranscriptomicsExpression data from Helicobacter pylori isolates infecting a gastric epithelial progenitor cell line
Helicobacter pylori clinical isolates can establish themselves in gastric epithelial stem cells and this interaction may have implications for gastric tumorigenesis. Mouse gastric epithelial progenitor cells (mGEPs) were infected for 24hrs with Helicobacter pylori clinical isolates Kx1 and Kx2. Kx1 ...
ORGANISM(S): Helicobacter pylori 
2010-05-26 | E-GEOD-10261 | biostudies-arrayexpress
ProteomicsSpatial distribution of endogenous tissue protease activity in gastric carcinoma mapped by MALDI mass spectrometry imaging
Aberrant protease activity has been implicated in the etiology of various prevalent diseases including neurodegeneration and cancer, in particular metastasis. Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has recently been established as a key technology for bio...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-25 | PXD010369 | Pride
Gastric mouse carcinoma Lc-ms Sp3 Proteases Maldi 
TranscriptomicsExpression data from mouse gastric tumor models
Transgenic mice with prostaglandin E2 pathway in stomach develops gastric tumors. Simultaneous activation of both Wnt pathway and prostaglandin E2 pathway causes gastric adenocarcinoma. Combination of prostaglandin E2 pathway activation and suppression of BMP pathway leads to the development of gast...
ORGANISM(S): Mus musculus 
2009-07-02 | E-GEOD-16902 | biostudies-arrayexpress
TranscriptomicsPotential Mechanism of Chinese herbal formula Sijunzi Decoction in Treating Gastric Cancer
Establishment 615 mouse subcutaneous tumor model using mouse derived gastric cancer cell lines (MFC)，and intervention with traditional Chinese medicine（Sijunzi Decoction）. The mice model were indived into Model group(model), early Sijunzi Decoction (E-SJZD), synchronization Sijunzi Decoction (S-SJZD...
ORGANISM(S): Mus musculus 
2025-10-31 | E-MTAB-15788 | biostudies-arrayexpress
MetabolomicsIntestinal Lachnospiraceae bacterium-derived Propionate Inhibits the Progression of Clear Cell Renal Cell Carcinoma
Gut microbiota has been reported to be associated with the development of various diseases, however, its interaction with clear cell renal cell carcinoma (ccRCC) remains unknown. To investigate the potential relationship between gut microbiota alteration and ccRCC development, we analyze feces from ...
2025-06-13 | MTBLS12539 | MetaboLights
TranscriptomicsTranscription profiling of mouse model of Helicobacter-induced gastric cancer
We have previously reported human gastrin overexpressing transgenic mice (=INS-GAS mice) and Helicobacter felis (=H.felis) infection synergistically accelerated gastric cancer in mice stomachs. (Wang et al 2000) Using this mouse model, we employed microarray analysis of gene expression profiling t...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4651 | biostudies-arrayexpress
TranscriptomicsHelicobacter pylori-mediated Epigenetic Dysregulation of FOXD3 Tumor-suppressive Cascade In Gastric Carcinogenesis [ChIP]
Forkhead box (Fox) proteins constitute an evolutionarily conserved family of transcriptional regulators whose deregulations lead to tumorigenesis. However, their regulation and function in gastric cancer are unknown. Promoter hypermethylation occurs during Helicobacter pylori (H pylori)-induced gast...
ORGANISM(S): Mus musculus 
2012-12-28 | E-GEOD-39490 | biostudies-arrayexpress
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