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MetabolomicsOral administration of low-molecular-weight heparin ameliorates colitis by enhancing the gut mucus barrier via microbial tryptophan metabolites

Background and Purpose: Previous studies have reported that oral low molecular weight heparin (LMWH) ameliorated colitis by undefined mechanisms in ulcerative colitis (UC) patients. Our study explored the mechanisms of LMWH on colitis from the perspective of gut microbiota and its metabolites.

2025-10-12 | MTBLS5770 | MetaboLights
ProteomicsPhysical, chemical, and structural properties of human gastric organoid-derived mucus
We explored the potential of human gastric organoids as models for mucus production. Immunofluorescence staining confirmed that the organoids produced mucus containing MUC5AC and MUC6. The luminal mucus had viscoelastic properties similar to those of native human gastric mucus, as determined by part...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2025-12-30 | PXD072060 | Pride
Gastric mucus layer  organoids  air-liquid interface  gastric epithelial barrier  microrheology  organoid lumen 
TranscriptomicsTranscription profiling of mouse gastric epithelial cell types: parietal, zymogenic, and pit
Continuous regeneration of digestive enzyme (zymogen) secreting chief cells is a normal aspect of stomach function that is disrupted in pre-cancerous lesions. Regulation of zymogenic cell (ZC) differentiation is poorly understood. Here we profile Parietal, Pit, and Zymogenic cells for comparison an...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5018 | biostudies-arrayexpress
TranscriptomicsCarbon nutrition of pathogenic and commensal E. coli
Transcriptome profiling of E. coli MG1655, E. coli EDL933, E. coli ECOR26, and E. coli Nissle 1917 grown on mouse cecal mucus as carbon source The carbon sources that support growth of pathogenic E. coli O157:H7 in the mammalian intestine have not previously been investigated. In vivo, pathogenic E...
ORGANISM(S): Escherichia coli 
2008-04-25 | E-GEOD-11254 | biostudies-arrayexpress
TranscriptomicsLubiprostone effects on small intestinal gene expression in wild type and Cftr-null mice
Background: Cystic fibrosis (CF) is caused by mutations in the CFTR gene that impair function of this cAMP-regulated Cl- channel. In the small intestine, loss of CFTR function creates a dehydrated, acidic luminal environment which is believed to cause an accumulation of mucus, a phenotype characteri...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-18327 | biostudies-arrayexpress
UnknownThe spatial orientation of Helicobacter pylori in the gastric mucus.
Not available
S-EPMC387367 | biostudies-literature
UnknownPrinciples of slowed hydrogen diffusion through a mucus layer.
Not available
S-EPMC11542194 | biostudies-literature
UnknownPhysical, chemical, and structural properties of human gastric organoid-derived mucus.
Not available
S-EPMC12642607 | biostudies-literature
TranscriptomicsArrays of time course experiment (2-28 d) laser microdissected samples of H. pylori -infected mice
Mice were infected with Helicobacter pylori strain SS1 for 2, 7, 14 or 28 days or left uninfected. They were sacrificed at the appropriate times, the stomachs were removed and one half was plated for colony counts. The other half was embedded in OCT and cryosections were produced for 6-7 animals per...
ORGANISM(S): Mus musculus 
2012-05-11 | E-GEOD-37938 | biostudies-arrayexpress
UnknownIdentification of Novel Glycans in the Mucus Layer of Shark and Skate Skin.
Not available
S-EPMC10532229 | biostudies-literature
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