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TranscriptomicsBone marrow dendritic cells response to LPS, PAM and poly IC
Individual genetic variation affects gene expression and cell phenotype by acting within complex molecular circuits, but this relationship is still largely unknown. Here, we combine genomic and meso-scale profiling with novel computational methods to detect genetic variants that affect the responsiv...
ORGANISM(S): Mus musculus 
2013-03-17 | E-GEOD-40452 | biostudies-arrayexpress
TranscriptomicsRNA-Seq global gene expression of four Dendritic cells subpopulations from lung (CD8+ and CD8- pDCs, CD103-CD11b+ and CD103+CD11b- cDCs) of influenza infected mice at four time points following infection
Hundreds of immune cell types work in coordination to maintain tissue homeostasis. Upon infection, dramatic changes occur with the localization, migration and proliferation of the immune cells to first alert the body of the danger, confine it to limit spreading, and finally extinguish the threat and...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-49932 | biostudies-arrayexpress
Proteomics,MultiomicsSystematic Discovery of TLR Signaling Components Delineates Viral-Sensing Circuits.
Chevrier N, Mertins P, Artyomov MN, Shalek AK, Iannacone M, Ciaccio MF, Gat-Viks I, Tonti E, DeGrace MM, Clauser KR, Garber M, Eisenhaure TM, Yosef N, Robinson J, Sutton A, Andersen MS, Root DE, von Andrian U, Jones RB, Park H; Carr SA, Regev A, Amit I, Hacohen N. Cell, 2011, 147(4) 853-867. doi: 10...
2013-12-10 | MSV000078507 | MassIVE
TranscriptomicsRNA-Seq global gene expression in lung tissue at ten time points during a 7-day time course of infection
Hundreds of immune cell types work in coordination to maintain tissue homeostasis. Upon infection, dramatic changes occur with the localization, migration and proliferation of the immune cells to first alert the body of the danger, confine it to limit spreading, and finally extinguish the threat and...
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-49933 | biostudies-arrayexpress
TranscriptomicsFlu infection
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-03-03 | E-GEOD-49934 | biostudies-arrayexpress
TranscriptomicsEZH2 promotes a bi-lineage identity in basal-like breast cancer cells
The mechanisms regulating breast cancer differentiation state are poorly understood. Of particular interest are molecular regulators controlling the highly aggressive and poorly differentiated traits of basal-like breast carcinomas. Here we show that the Polycomb factor EZH2 maintains the differenti...
ORGANISM(S): Homo sapiens 
2012-09-21 | E-GEOD-36939 | biostudies-arrayexpress
ProteomicsDysregulated Proteolysis of Extracellular Matrix Proteins Regulates Influenza and Pneumonia Co-infection Associated Mortality
The balance between tissue integrity and efficient immune response is critical for host survival. Here we investigate the role of extra cellular matrix (ECM)-remodeling events in the lung during influenza infection. Using an unbiased genomic and proteomic approach we follow the dynamics of gene and ...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-19 | PXD004871 | Pride
Influenza Pneumonia Extracellular matrix proteins 
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