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ProteomicsThe GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation
Sestrins represent a family of stress-inducible proteins that prevent the progression of many age- and obesity-associated disorders. Endogenous Sestrins maintain insulin-dependent AKT Ser/Thr kinase (AKT) activation during high-fat diet (HFD)-induced obesity, and overexpressed Sestrins activate AKT ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-15 | PXD015824 | Pride
Sestrin2 Akt pkb Liver metabolism Gator2 Mtor 
UnknownStructure of the nutrient-sensing hub GATOR2.
Not available
S-EPMC9464592 | biostudies-literature
UnknownGATOR2 complex-mediated amino acid signaling regulates brain myelination.
Not available
S-EPMC8784133 | biostudies-literature
UnknownStructural basis for mTORC1 regulation by the CASTOR1-GATOR2 complex.
Not available
S-EPMC12477443 | biostudies-literature
UnknownSeh1 targets GATOR2 and Nup153 to mitotic chromosomes.
Not available
S-EPMC5992584 | biostudies-literature
UnknownThe GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Not available
S-EPMC7029113 | biostudies-literature
GenomicsRbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component, Mios
Rbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component, Mios
PRJNA1072072 | ENA
TranscriptomicsRbpms2 promotes female fate upstream of the nutrient sensing Gator2 complex component, Mios
Reproductive success relies on proper establishment and maintenance of biological sex. In many animals, including mammals, the primary gonad is initially ovary in character. We previously showed the RNA binding protein (RNAbp), Rbpms2, is required for ovary fate in zebrafish. Here, we identified Rbp...
ORGANISM(S): Danio rerio 
2024-06-06 | GSE254850 | GEO
UnknownThe GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs.
Not available
S-EPMC10940221 | biostudies-literature
UnknownThe Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.
Not available
S-EPMC4223866 | biostudies-literature
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