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ProteomicsThe GATOR2–mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation
Sestrins represent a family of stress-inducible proteins that prevent the progression of many age- and obesity-associated disorders. Endogenous Sestrins maintain insulin-dependent AKT Ser/Thr kinase (AKT) activation during high-fat diet (HFD)-induced obesity, and overexpressed Sestrins activate AKT ...
ORGANISM(S): Homo sapiens (Human) 
2020-01-15 | PXD015824 | Pride
Sestrin2 Akt pkb Liver metabolism Gator2 Mtor 
UnknownLeucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Not available
S-EPMC4899281 | biostudies-literature
UnknownSestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
Not available
S-EPMC4314228 | biostudies-literature
UnknownCorrelation between sestrin2 expression and airway remodeling in COPD.
Not available
S-EPMC7667887 | biostudies-literature
UnknownSestrin2 ameliorates diabetic retinopathy by regulating autophagy and ferroptosis.
Not available
S-EPMC10991044 | biostudies-literature
UnknownSestrin2 is a leucine sensor for the mTORC1 pathway.
Not available
S-EPMC4698017 | biostudies-literature
UnknownSestrin2 Expression Has Regulatory Properties and Prognostic Value in Lung Cancer.
Not available
S-EPMC7565522 | biostudies-literature
UnknownSerum Sestrin2 Was Lower in Septic Shock Patients with Cardiomyopathy
Not available
S-EPMC9458382 | biostudies-literature
UnknownThe apo-structure of the leucine sensor Sestrin2 is still elusive.
Not available
S-EPMC5087270 | biostudies-literature
UnknownThe GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation.
Not available
S-EPMC7029113 | biostudies-literature
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