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ProteomicsProteomic of grass carp (Ctenopharyngodon Idella) five tissues before and after GCRV infection
Hemorrhagic disease caused by grass carp reovirus (GCRV) infection is a major problem affecting the grass carp aquaculture industry. Therefore, inhibiting the spread of GCRV infection is of great economic significance. Herein, we sequenced five tissues (gill, liver, intestine, kidney, and muscle) fr...
ORGANISM(S): Ctenopharyngodon Idella 
2024-10-20 | PXD056989 |
ProteomicsAnti-hsp70 pull down CIK cells lysis infected GCRV and MS for identify the proteins
HSP70 of grass carp and outer capsid protein VP7 of GCRV determines the early stage of viral entry. Multi-transcriptomic analysis identified HSP70 as a key player in the pathogenesis of GCRV infection. Temperature-dependent, and primarily plasma membrane anchored HSP70 interacts with VP7 to facilita...
ORGANISM(S): Ctenopharyngodon idella 
2023-05-09 | PXD036008 | Pride
Gcrv Hsp70 Ctenopharyngodon idella Receptor 
MetabolomicsViral-Induced Heme Accumulation Subverts TLR4bb-Mediated Antiviral Immunity by Triggering Gut Microbiota Dysbiosis, Metabolic Dysregulation, and Ferroptosis

This study identifies grass carp TLR4bb as a crucial hub coordinating antiviral immunity with heme metabolism, redox balance, and gut microbiota during GCRV-II infection. While TLR4bb recruits TIRAP/MyD88/TRIF to activate IFN signaling against the virus, its synergy with heme and viral sensing tr...

2026-01-23 | MTBLS13755 | MetaboLights
UnknownITGB1b-Deficient Rare Minnows Delay Grass Carp Reovirus (GCRV) Entry and Attenuate GCRV-Triggered Apoptosis.
Not available
S-EPMC6214113 | biostudies-literature
UnknownBid-deficient fish delay grass carp reovirus (GCRV) replication and attenuate GCRV-triggered apoptosis.
Not available
S-EPMC5652715 | biostudies-literature
TranscriptomicsCRISPR/Cas9 mutagenesis reveals an essential role of PI4KB in promoting growth and resisting hemorrhagic disease caused by GCRV-II infection in juvenile grass carp
Few studies reported for obtaining the grass carp resistant to hemorrhagic disease via gene editing in commercial fish. Here, we demonstrate that the expression and activity of grass carp PI4KB (gcPI4KB) are vital for GCRV-I and GCRV-II replication. Due that obvious cytopathic effect (CPE) in the pr...
ORGANISM(S): Ctenopharyngodon idella 
2025-09-30 | GSE273923 | GEO
UnknownAnalysis of GCRV Pathogenesis and Therapeutic Measures Through Proteomic and Metabolomic Investigations in GCRV-Infected Tissues of Grass Carp (Ctenopharyngodon idella).
Not available
S-EPMC11546743 | biostudies-literature
UnknownAutophagy Inhibits Grass Carp Reovirus (GCRV) Replication and Protects Ctenopharyngodon idella Kidney (CIK) Cells from Excessive Inflammatory Responses after GCRV Infection.
Not available
S-EPMC7564910 | biostudies-literature
UnknownGrass carp SERPINA1 inhibits GCRV infection through degrading CF2.
Not available
S-EPMC9494734 | biostudies-literature
UnknownGCRV-II Triggers B and T Lymphocyte Apoptosis via Mitochondrial ROS Pathway.
Not available
S-EPMC12298793 | biostudies-literature
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