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TranscriptomicsSensitive and robust gene expression changes in fish exposed to estrogen - a microarray approach
Background
Vitellogenin is a well established biomarker for estrogenic exposure in fish. However, effects on gonadal differentiation at concentrations of estrogen not sufficient to give rise to a measurable vitellogenin response suggest that more sensitive biomarkers would be useful. Induction of...
ORGANISM(S): Oncorhynchus mykiss 
2007-07-24 | E-MEXP-1149 | biostudies-arrayexpress
TranscriptomicsSevere Hypoxia Exerts Parallel and Cell-specific Regulation of Gene Expression and Alternative Splicing in Human Mesenchymal Stem CellsMesenchymal Stem Cells
To identify the effects of hypoxia on stem cell populations, we subjected human mesenchymal stem cells to a pO2 of 4 mmHg and analyzed global gene expression and alternative splicing (AS) by genome-exon microarray. Hypoxia induced gene expression in human mesenchymal stem cells was measured at 24 h...
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-55875 | biostudies-arrayexpress
ProteomicsProteomic identification of MHC class I-associated peptidome derived from non-obese diabetic mouse thymus and pancreas
The peptides repertoire presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules, referred to as the MHC I-associated peptidome (MIP), regulates all critical events that occur during the lifetime of CD8+ T cells. The MIP presented by thymic antigen presenting cells (APCs...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031966 | Pride
Pancreas Lc-ms/ ms Nod mouse Mhc class i-associated peptidome T1d Cd8+ t-cell. Thymus 
ProteomicsUbiquitin Thioesterase OTUB2 is An Endoplasmic Reticulum Stress-associated β Cell Autoantigen Targeted by CD8+ T cells in Type 1 Diabetes
Autoreactive CD8+ T cell plays a key role in the pathogenesis of Type 1 diabetes (T1D), but the antigen spectrum that activate autoreactive CD8+ T cells is still not completely clear. Endoplasmic reticulum stress（ERS）has been implicated in the generation of β cell autoantigens and the enhanced immun...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD041227 | Pride
Otub2 Endoplasmic reticulum stress Type 1 diabetes Cd8+ t-cell. 
TranscriptomicsTranscriptomic profile of yeast cells lacking the high affinity K+-transport system
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24711 | biostudies-arrayexpress
TranscriptomicsLack of the pif1 helicase enhances zinc tolerance in S. cerevisiae
The Saccharomyces cerevisiae gene PIF1 encodes a conserved eukaryotic DNA helicase required for both mitochondrial and nuclear DNA integrity. Our previous work revealed that a pif1D strain is tolerant to zinc overload. We demonstrate here that this effect is independent of the Pif1 helicase activity...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-31 | E-GEOD-18411 | biostudies-arrayexpress
TranscriptomicsTranscriptomic changes induced in yeast cells by the lack of potassium in the medium
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24712 | biostudies-arrayexpress
TranscriptomicsA spatiotemporal understanding of growth regulation during the salt-stress response (Agilent)
A genome-scale test of dynamic gene expression changes and homeostasis in salt stress response was genereated using whole roots sample of wild type columbia. Seedlings of columbia were grown under standard conditions for 5 days, and then they were transfered to media supplemented with 140mM NaCl for...
ORGANISM(S): Arabidopsis thaliana 
2013-09-01 | E-GEOD-46208 | biostudies-arrayexpress
TranscriptomicsGene expression comparison of colorectal cancer samples from patients diagnosed at a young and elderly age
Colorectal cancer (CRC) incidence increases with age and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30 % of all CRC cases. To identify genes associated with an increased risk for CRC, genome-wide gene expression levels of CRCs from patients diagno...
ORGANISM(S): Homo sapiens 
2011-09-06 | E-GEOD-25071 | biostudies-arrayexpress
TranscriptomicsDifferential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer model (expression)
The cellular heterogeneity of one patient derived orthotopic breast cancer xenograft model (PDBCX) was investigated using flow cytometry , combined with assessment of in vivo tumorigenicity and whole genome expression profiling. Epithelial cell adhesion molecule (EpCAM) was revealed as a highly spec...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-48384 | biostudies-arrayexpress
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