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TranscriptomicsExpression mRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinson’s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77666 | biostudies-arrayexpress
TranscriptomicsExpression miRNA data from human postmortem putamen samples measured using the NanoString nCounter platform
Background: Molecular adaptations in the striatum mediated by dopamine (DA) denervation or Levodopa (L-dopa) treatment have been implicated with the motor deficits found in Parkinsonâ??s disease (PD). Alterations in glutamatergic neurotransmission and anti-oxidant mechanisms are reported to play imp...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-77667 | biostudies-arrayexpress
GenomicsGenome-wide map of lysine specific demethylase 1 (LSD1) in mouse embryonic stem cells.
We report the identification of LSD1 binding genomic regions in mouse embryonic stem cells (ESC) by high throughput sequencing. By obtaining over 10 million 36 bp reads of sequence from each chromatin immunoprecipitated DNA, we generated genome-wide maps for LSD1 and histone H3 dimethylated on lysin...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-18515 | biostudies-arrayexpress
TranscriptomicsLEOPARD Syndrome iPS, BJ iPS and Fibroblasts
Expression data from LEOPARD Syndrome-iPS clones, BJ-iPS cells and parental Fibroblasts 9 samples in total are analyzed. Among 22011 genes in expression data, there are 3657 genes with at least 2 fold expression change between the average of the three fibroblast lines versus all of the iPS lines/HE...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20473 | biostudies-arrayexpress
GenomicsWdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and epigenetic networks are critical for the maintenance of ES cell self-renewal. However, it remains unclear whether components of these networks functionally interact and if so, what factors mediate such interactions. Here we show that WD-repeat protein...
ORGANISM(S): Mus musculus 
2011-04-08 | E-GEOD-22934 | biostudies-arrayexpress
TranscriptomicsTranscriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury
Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multice...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-57387 | biostudies-arrayexpress
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