Gef-h1 - OmicsDI

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2014 (24)
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CHEBI ID

CHEBI:143106 (1)
CHEBI:81810 (1)
CHEBI:166563 (1)
CHEBI:139445 (1)
CHEBI:41094 (1)
CHEBI:167860 (1)
CHEBI:167740 (1)
CHEBI:183489 (1)
CHEBI:193016 (1)
CHEBI:183418 (1)
CHEBI:183375 (1)
CHEBI:177535 (1)
CHEBI:25682 (1)
CHEBI:52153 (1)
CHEBI:34187 (1)
CHEBI:7027 (1)
CHEBI:67040 (1)
CHEBI:15890 (1)
CHEBI:31445 (1)
CHEBI:15694 (1)
CHEBI:31747 (1)
CHEBI:17061 (1)
CHEBI:177850 (1)
CHEBI:143235 (1)
CHEBI:16523 (1)
CHEBI:165632 (1)
CHEBI:16269 (1)
CHEBI:66892 (1)
CHEBI:132583 (1)
CHEBI:41308 (1)

Metabolite Name

Uridine 5'-diphosphoglucuronic acid (1)
2,5-di-tert-Butylhydroquinone (1)
L-Glutathione (reduced) (1)
N-Acetyl-1-aspartylglutamic acid (1)
Uridine 5'-diphosphogalactose (1)
L-Glutathione oxidized (1)
Uridine monophosphate (UMP) (1)
Guanosine monophosphate (GMP) (1)
Cyclic ADP-ribose (1)
AICA ribonucleotide (1)
Thymidine 5'-monophosphate (1)
Folic acid (1)
S-Lactoylglutathione (1)
UDP-N-acetylglucosamine (1)
(+/-)12(13)-DiHOME (1)
D-Raffinose (1)
Adenosine 5'-monophosphate (1)
DL-Tryptophan (1)
Adenosine diphosphate (ADP) (1)
(+/-)9-HpODE (1)
Pantothenic acid (1)
Gluconic acid (1)
Citric acid (1)
(15Z)-9,12,13-Trihydroxy-15-octadecenoic acid (1)
Dibutyl phthalate (1)
Adenosine (1)
Uridine 5'-diphosphate (UDP) (1)
Tetradecanedioic acid (1)
Palmitic acid (1)
N-Acetyl-L-phenylalanine (1)

First Public Date

2026 (3)
2025 (2)
2019 (2)
2022 (1)
2020 (1)

Study type

Transcription profiling by array (41)
RNA-seq of coding RNA (17)
ChIP-seq (14)
ChIP-chip by tiling array (7)
Comparative genomic hybridization by array (7)
RNA-seq of coding RNA from single cells (6)
Other (5)
High-throughput sequencing (3)
ChIP-chip by array (3)
Methylation profiling by array (3)
Single nucleus RNA sequencing (2)
RNA-seq of total RNA (2)
Transcription profiling by SAGE (1)
Unknown experiment type (1)
RIP-chip by array (1)
Transcription profiling by RT-PCR (1)
ScATAC-seq (1)
Proteomic profiling by array (1)
RNA-seq of non coding RNA (1)

Release Date

2014 (26)
2016 (16)
2010 (13)
2021 (13)
2026 (12)
2012 (12)
2011 (12)
2013 (11)
2025 (10)
2020 (10)
2015 (10)
2009 (10)
2019 (8)
2024 (7)
2023 (7)
2022 (7)
2018 (6)
2017 (5)
2008 (4)
2007 (2)
2003 (2)
2006 (1)
2004 (1)

Lab affiliation

CAncer Biology Lab, Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina (1)
CRUK - Beatson Institute for Cancer Research - Switchback Rd, Bearsden, Glasgow G61 1BD - United Kingdom (1)
Cancer Biology lab, Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina (1)
Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Padualaan, Utrecht, 3584 CS, The Netherlands (1)
Chair of Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, Würzburg, Germany (1)
Department of Urology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA (1)
Head of the Curie Institute Mass Spectrometry Platform (1)

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Taxane-Induced Conformational Changes in the Microtubule Lattice Activate GEF-H1-Dependent RhoA Signaling

Taxanes are widely used chemotherapeutic agents that perturb cell division. They also exert effects during interphase, but the underlying mechanisms are poorly understood. Here, we show that taxanes activate RhoA signaling and induce actin remodeling by displacing the RhoA activator GEF-H1 from micr...

ORGANISM(S): Homo sapiens (Human)

2026-08-20 | PXD079708 | Pride

Hypoxia inhibits HUNK-mediated phosphorylation of GEF-H1 for epithelial-to-mesenchymal transition

PRJNA840881 | ENA

GEF-H1 mediated gene expression changes in BMDCs in response to microtubule destabilization

PRJNA558066 | ENA

GEF-H1-IRF5 mediated gene expression changes in BMDM by MDP recognition

PRJNA523187 | ENA

Hypoxia inhibits HUNK-mediated phosphorylation of GEF-H1 for epithelial-to-mesenchymal transition

Hypoxia regulates epithelial to mesenchymal transition (EMT) of cancer cells. However, the mechanism underlying hypoxia-mediated EMT remains largely unknow. Here, utilizing colorectal cell carcinoma (CRC) as a model, we find that HUNK inhibits EMT and suppresses metastasis of CRC cells via its subst...

ORGANISM(S): Homo sapiens

2022-05-27 | GSE203440 | GEO

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF.

Not available

S-EPMC5085165 | biostudies-literature

GEF-H1 mediated gene expression changes in BMDCs in response to microtubule destabilization

GEF-H1 controls transcriptional programs that mediate antitumor immuity upon microtubule destabilization.

ORGANISM(S): Mus musculus

2019-10-01 | GSE135264 | GEO

GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation.

Not available

S-EPMC5057286 | biostudies-literature