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TranscriptomicscaArray_golub-00392: Gefitinib (Iressa) induces myeloid differentiation of acute myeloid leukemia
Cure rates for patients with acute myeloid leukemia (AML) remain low despite ever-increasing dose intensity of cytotoxic therapy. In an effort to identify novel approaches to AML therapy, we recently reported a new method of chemical screening based on the modulation of a gene expression signature o...
ORGANISM(S): Homo sapiens 
2015-05-16 | E-GEOD-68954 | biostudies-arrayexpress
TranscriptomicsmiRNA array analysis following gefinitib/luteolin administration to PC-3 cells
To determine if any altered miRNA expression is actually involved in the growth inhibition and/or cell death induction by luteolin and/or gefitinib, we performed miR-array analysis using RNA from PC-3 cells after 24h of treatment with 60μM luteolin and/or 60μM gefitinib. PC-3 cells were treated fo...
ORGANISM(S): Homo sapiens 
2014-06-29 | E-GEOD-53178 | biostudies-arrayexpress
TranscriptomicsNSCLC cells treated with Gefitinib
About 10% of all NSCLC patients respond to gefitnib treatment and all of these patients will acquire resistance to the EGFR TKI. We used microarray to look at global gene expression changes in untreated cells vs gefitinib treated cells to identify key characters for the acquisition of resistance. NS...
ORGANISM(S): Homo sapiens 
2011-01-27 | E-GEOD-23206 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of non squamous cell lung cancer cell lines to investigate sensititivity to gefitinib and predict this in previously untested cell lines
Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-4342 | biostudies-arrayexpress
TranscriptomicsTime-course gene expression profiles of gefitinib-sensitive or -resistant lung adenocarcinoma cells stimulated with EGF, in the presence or absence of gefitinib, EGF receptor tyrosine kinase-specific inhibitor
Gefitinib, an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), induces substantial clinical responses for non-small cell lung cancer (NSCLC) cells harboring EGFR activating mutations, but most of them invariably develop resistance. By generating a gefitinib resistance (PC9GR)...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-34228 | biostudies-arrayexpress
GenomicsGefitinib treatment in human EGFR-driven-Gefitinib resistant tumoral cell line
Gefitinib treatment in human EGFR-driven-Gefitinib resistant tumoral cell line
PRJNA483409 | ENA
ProteomicsIntegrative analysis of proteome and ubiquitylome reveals unique features of protein ubiquitylation and mitochondria in gefitinib resistant non-small cell lung cancer cells
Even though gefitinib, a tyrosine kinase inhibitor, widely used in treating non-small cell lung cancer (NSCLC) patients carrying EGFR activating mutations, most patients will develop gefitinib resistance. Protein ubiquitylation is one of major posttranslational modifications affecting the stab...
ORGANISM(S): Homo sapiens (Human) 
2018-07-05 | PXD004941 | Pride
Human Lc_msms Lung Non-small cell lung cancer cells 
TranscriptomicsTranscription profiling by array of human wild type and gefitinib-resistant A431 cancer cells
A431 wild-type (wt) cancer cell line is sensitive to treatment with EGFR tyrosine kinase inhibitors (TKIs). By culturing it chronically under gefitinib, it eventually becomes resistant (A431_GR cell). We know of a few proteins involved in this mechanism of drug resistance, but a cDNA exprssion array...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-10696 | biostudies-arrayexpress
ProteomicsGefitinib results in robust host-directed immunity against Salmonella infection through proteo-metabolomic reprogramming.
The rise of antibiotic-resistant strains of Salmonella has demand the development of alternative therapeutic strategies. Recent studies have shown that targeting host factors may provide an alternative approach for the treatment of intracellular pathogens. Host-directed therapy (HDT) modulates host ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-26 | PXD024771 | Pride
Salmonella Proteo-metabolomic Dia Swath-ms Thp-1 
TranscriptomicsRNA-seq of A431 cell line after gefitinib treatment
RNA sequencing of A431 cell line samples before and after gefitinib treatment, at 0, 2, 6 and 24 hours, was performed in order to characterize the cell line's early and late response to this drug, and to compare against proteomics (mass spectrometry) characterization of the cell line using the same ...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-5285 | biostudies-arrayexpress
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