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TranscriptomicsmicroRNA profiling by array of gemcitabine sensitive BxPC-3 pancreatic cancer cell lines and their derived resistant subclones, Bx-GEM
This experiment describes the differential microRNA expression between parental gemcitabine-sensitive BxPC-3 cells and their resistant subclones, Bx-GEM. To select for the resistant subclones, parental BxPC-3 cells were treated with increasing concentrations of gemcitabine (10, 25, 50, 100 and 200 n...
ORGANISM(S): Homo sapiens 
2017-01-20 | E-MTAB-4927 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of gemcitabine sensitive BxPC-3 pancreatic cancer cell lines and their derived resistant subclones, Bx-GEM
This experiment describes the differential gene expression between parental gemcitabine-sensitive BxPC-3 cells and their resistant subclones, Bx-GEM. To select for the resistant subclones, parental BxPC-3 cells were treated with increasing concentrations of gemcitabine (10, 25, 50, 100 and 200 nM) f...
ORGANISM(S): Homo sapiens 
2017-01-20 | E-MTAB-4901 | biostudies-arrayexpress
TranscriptomicsGene Expression of human bladder cancer cell line RT112 and Gemcitabine Resistant Bladder Cancer cell line RT112-Gr
In this research, Human OneArray Microarray analysis was performed to obtain broad spectrum information about the genes differentially expressed in human bladder cancer cell line RT112 and Gemcitabine Resistant Bladder Cancer cell line RT112-Gr.
ORGANISM(S): Homo sapiens 
2015-04-16 | E-MTAB-3495 | biostudies-arrayexpress
TranscriptomicsGene expression signature of gemcitabine resistance in human pancreatic cancer cell lines
We examined the microarray-based expression profiles of the cells to identify genes associated with gemcitabine resistance Using three set of parental and resistant cell lines, PK-9 and RPK-9, PK-1 and RPK-1, and PK-59 and RPK-59, we studied mRNA transcription levels by microarray analysis to see if...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-35141 | biostudies-arrayexpress
TranscriptomicsPemetrexed and gemcitabine as combination therapy for the treatment of Group3 medulloblastoma
We devised a high-throughput, cell-based assay to identify novel therapeutic compounds to treat Group3 medulloblastoma (G3 MB). Mouse G3 MBs, grown as neurospheres, were screened against a library of approximately 7,000 compounds including FDA-approved drugs. We identified two FDA-approved drugs, ...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-46406 | biostudies-arrayexpress
TranscriptomicsExpression microarray analysis of acquired gemcitabine resistance
This series repressents the data set from the paper "Expression microarray analysis and oligo array CGH of aquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations". Biological material: One solid mouse tumor "Colon 26A" was routinely maintained by successive tran...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-2352 | biostudies-arrayexpress
TranscriptomicsStudy of microRNA associated with the anti-tumor effect of gemcitabine
The miRNAs expression was markedly altered with the treatment of gemcitabine on human CCC cells in vitro. And various miRNAs induced by gemcitabine may contribute to tumor regression in vitro. Using a custom microarray platform, we analyzed the expression levels of 2555 human miRNA probes in the ce...
ORGANISM(S): Homo sapiens 
2016-04-01 | E-GEOD-67257 | biostudies-arrayexpress
TranscriptomicsMolecular Profiling of Breast Cancer Cells after Gemcitabine exposure
Human breast cancer cell lines were exposed to IC50 gemcitabine (Gemzar) for 24 and 48 hours. RNA was extracted, amplified and hibridized onto Oncochip microarray slides. Human breast carcinoma cell lines MCF7 and MDA-MB-231 were cultured in DMEM with Glutamax-1, supplemented with 10% fetal bovine s...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-4937 | biostudies-arrayexpress
TranscriptomicsArray CGH on gemcitabine resistant tumor
Biological material: One solid mouse tumor "Colon 26A" was routinely maintained by successive transplantation. A subset of mice with this tumor was treated at the maximum tolerable dosage of Gemcitabine and successively transplanted 5 times and similarly treated. The last passage was completly resis...
ORGANISM(S): Mus musculus 
2010-06-05 | E-GEOD-2373 | biostudies-arrayexpress
TranscriptomicsHuman pancreatic adenocarcinoma contains a side population resistant to gemcitabine
BACKGROUND: Therapy resistance remains one of the major challenges to improve the prognosis of patients with pancreatic cancer. Chemoresistant cells, which potentially also display cancer stem cell (CSC) characteristics, can be isolated using the side population (SP) technique. Our aim was to search...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-36563 | biostudies-arrayexpress
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