Expression microarray analysis of acquired gemcitabine resistance
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Paul van den IJssel
PROVIDER: E-GEOD-2352 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations.
van de Wiel Mark A MA Costa Jose L JL Smid Kees K Oudejans Cees B M CB Bergman Andries M AM Meijer Gerrit A GA Peters Godefridus J GJ Ylstra Bauke B
Cancer research 20051101 22
Gemcitabine is a commonly used therapy for many solid tumors. Acquired resistance to this nucleoside analogue, however, diminishes the long-term effectiveness in a majority of patients. To better define the molecular background of gemcitabine resistance, a mouse colon tumor was selected during successive rounds of transplantation with continued treatment of gemcitabine. Expression microarray analysis was applied to determine which genes are consistently and highly overexpressed or underexpressed ...[more]
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