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ProteomicsSwapped genetic code block viral infections and gene transfer
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially re...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-08 | MSV000089854 | MassIVE
ProteomicsEvolutionary Instability of CUG-Leu in the Genetic Code of Budding Yeasts
The standard genetic code is almost universal, and the evolutionary factors that caused a few organisms to deviate from it are poorly understood. We report that three independent changes of the genetic code occurred during the evolution of budding yeasts, each of which was a reassignment of the codo...
ORGANISM(S): Komagataella phaffii Babjeviella inositovora [Candida] boidinii Lipomyces starkeyi Kuraishia capsulata Nakazawaea wickerhamii Peterozyma xylosa Ascoidea rubescens Citeromyces matritensis Pachysolen tannophilus Saturnispora dispora Tortispora caseinolytica Ambrosiozyma philentoma Candida parapsilosis Pichia kudriavzevii Cyberlindnera jadinii Ogataea polymorpha Saccharomycopsis capsularis 
2018-05-21 | PXD008827 | Pride
Genetic code yeast cug 
TranscriptomicsTranscription profiling of yeast expressing wild type C. albicans G33 ser-tRNACAG and the mutant T33 ser-tRNACAG which trigger genetic code ambiguity
S. cerevisiae expressing the wild-type C. albicans G33 ser-tRNACAG and the mutant T33 ser-tRNACAG that trigger genetic code ambiguity were compared against control yeast using two-color oligo arrays
ORGANISM(S): Saccharomyces cerevisiae 
2007-11-08 | E-TABM-196 | biostudies-arrayexpress
ProteomicsTranslation machinery for deliberate mistranslation of the genetic code in Bacteria
“Inaccurate” expression of the genetic code, also known as mistranslation, is an emerging paradigm in microbial studies. Growing evidence indicates that many microbial pathogens can deliberately mistranslate their genetic code to help invade a host or evade host immune responses. However, discoverin...
ORGANISM(S): Escherichia coli 
2022-02-22 | PXD026636 | Pride
Aminoacyl-trna synthetase Trna Mistranslation Genetic code 
GenomicsDNA sequencing of selected Globobulimina pseudospinescens organisms
We introduce FACIL (http://www.cmbi.ru.nl/FACIL), a fast, reliable tool to evaluate nucleic acid sequences for non-standard codes that detects alternative genetic codes even in species distantly related to known organisms. Results are visualized in a Genetic Code Logo. To illustrate the use of our m...
ORGANISM(S): Globobulimina pseudospinescens 
2011-06-20 | E-GEOD-26664 | biostudies-arrayexpress
ProteomicsGenetic code expansion reveals site-specific lactylation in living cells reshapes protein function
Genetic code expansion reveals site-specific lactylation in living cells reshapes protein function
ORGANISM(S): Homo Sapiens 
2023-12-26 | PXD048127 |
ProteomicsChimeric design of Pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion
An orthogonal aminoacyl-tRNA synthetase/tRNA pair is a key prerequisite for site-specific incorporation of unnatural amino acids. Due to its high codon suppression efficiency and full orthogonality, the pyrrolysyl-tRNA synthetase/pyrrolysyl-tRNA pair is currently the ideal system for genetic code ex...
ORGANISM(S): Escherichia coli 
2020-05-25 | PXD018660 | Pride
Chimeric design Genetic code expansion 
ProteomicsMeasuring the tolerance of the genetic code to altered codon size
Measurement of the amino acid incorporation of tRNAs engineered to decode four-base codons.
ORGANISM(S): Escherichia coli 
2022-03-02 | PXD031925 | Pride
Synthetic biology Genetic code expansion 
ProteomicsNatural human tRNAAla anticodon variants mistranslate the genetic code
Transfer RNAs (tRNAs) play an essential role in protein synthesis by linking the nucleic acid sequences of gene products to the amino acid sequences of proteins. Although only 32 tRNAs are needed to decode all 61 sense codons in the genetic code, there are > 400 functional tRNA genes in the humans. ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD053463 | Pride
Anticodon Transfer rna Alanine Mistranslation Missense suppression Protein synthesis 
GenomicsThe Genetic Architecture of Congenital Diarrhea and Enteropathy (CODE)
The Genetic Architecture of Congenital Diarrhea and Enteropathy (CODE)
PRJNA1102436 | ENA
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