Sort   by:  
 Page size 
TranscriptomicsLoss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling
Transfer RNA (tRNA) modifications enhance the efficiency, specificity and fidelity of translation in all organisms. The anticodon modification mcm5s2U34 is required for normal growth and stress resistance in yeast; mutants lacking this modification have numerous phenotypes. Mutations in the homologo...
ORGANISM(S): Saccharomyces cerevisiae 
2013-08-01 | E-GEOD-45366 | biostudies-arrayexpress
ProteomicsQuantifying mistranslation from alanine tRNA anticodon variants in S. cerevisiae
Transfer RNAs (tRNAs) maintain translational fidelity through strict charging by their cognate aminoacyl-tRNA synthetase and codon:anticodon base pairing with the mRNA at the ribosome. Mistranslation occurs when an amino acid not specified by the genetic code is incorporated into a protein. Since al...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-02 | PXD038242 | Pride
Lc-msms Mistranslation Trna variants Yeast 
ProteomicsTranslation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
The precise interplay between the mRNA codon and the tRNA anticodon is crucial for ensuring efficient and accurate translation by the ribosome. The insertion of RNA nucleobase derivatives in the mRNA allowed us to modulate the stability of the codon-anticodon interaction in the decoding site of bact...
ORGANISM(S): Homo sapiens (Human) 
2018-11-21 | PXD011301 | Pride
Translation elongation Ribosome Decoding Codon-anticodon interactions Biological Nucleotide modifications 
ProteomicsTranslation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
The precise interplay between the mRNA codon and the tRNA anticodon is crucial for ensuring efficient and accurate translation by the ribosome. The insertion of RNA nucleobase derivatives in the mRNA allowed us to modulate the stability of the codon-anticodon interaction in the decoding site of bact...
ORGANISM(S): Escherichia coli 
2018-11-21 | PXD011311 | Pride
Translation elongation Ribosome Decoding Codon-anticodon interactions Biological Nucleotide modifications 
GenomicsA Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding
PRJNA1273852 | ENA
TranscriptomicsA Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding
Pseudouridine (Ψ) is known for decades, but its flexibility in base-pairing remains unclear. This study engineers artificial box H/ACA guide RNAs to direct pseudouridylation at the uridine of a premature termination codon (PTC; UAA, UAG, or UGA) within an intron-less mRNA and U36 of the anticodon of...
ORGANISM(S): Saccharomyces cerevisiae 
2025-06-20 | GSE299290 | GEO
GenomicstRNA anticodon loop branching by a widespread toxin
DUF1814 family toxin AbiEii inhibits translation by branching tRNA anticodon loop
PRJEB113038 | ENA
ProteomicsNatural human tRNAAla anticodon variants mistranslate the genetic code
Transfer RNAs (tRNAs) play an essential role in protein synthesis by linking the nucleic acid sequences of gene products to the amino acid sequences of proteins. Although only 32 tRNAs are needed to decode all 61 sense codons in the genetic code, there are > 400 functional tRNA genes in the humans. ...
ORGANISM(S): Homo sapiens (Human) 
2025-03-07 | PXD053463 | Pride
Anticodon Transfer rna Alanine Mistranslation Missense suppression Protein synthesis 
UnknownImportance of a tRNA anticodon loop modification and a conserved, noncanonical anticodon stem pairing in tRNACGGProfor decoding
Not available
S-EPMC6462517 | biostudies-literature
GenomicsmRNA regulation by tRNA synthetase through an anticodon mimic
mRNA association by aminoacyl tRNA synthetase occurs at an anticodon mimic and autoregulates translation in response to tRNA levels
PRJEB30963 | ENA
Sort   by:  
 Page size