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MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
ProteomicsAutoinhibition of Trio guanine nucleotide exchange factor activity for Rac1 by its spectrin repeats is disrupted by neurodevelopmental disorder-related genetic variants
Crosslinking MS of SR6-GEF1 construct of Human Trio. BS3 crosslinking of wild-type and three point mutants implicated in neurodevelopmental disorders (E883D, R1078Q, D1368V). Data acquired using FAIMS ion mobility source with each sample acquired at 4 different CVs (-40, -50, -60, -70V).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-08 | MSV000089621 | MassIVE
ProteomicsSwapped genetic code block viral infections and gene transfer
Removing cellular transfer RNAs (tRNAs), making their cognate codons unreadable, creates a genetic firewall that prevents viral replication and horizontal gene transfer. However, numerous viruses and mobile genetic elements encode parts of the translational apparatus, including tRNAs, potentially re...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-08 | MSV000089854 | MassIVE
ProteomicsGenetic exchange in leishmania is facilitated by IgM natural antibodies.
Proteomics of IgM-mediated clumped vs control parasites.
ORGANISM(S): Leishmania major strain Friedlin 
2023-08-20 | PXD038652 | Pride
Igm Genetic exchange Leishmania 
TranscriptomicsThe distribution of mobile genetic elements (MGEs) in MRSA CC398 is associated with both host and country.
Methicillin-resistant Staphylococcus aureus clonal complex (CC) 398 has emerged from pigs to cause human infections in Europe and North America. We used a new 62-strain S. aureus microarray (SAM-62) to compare genomes of isolates from three geographical areas (Belgium, Denmark, and Netherlands) to u...
ORGANISM(S): Staphylococcus aureus 
2012-01-21 | E-BUGS-120 | biostudies-arrayexpress
GenomicsCenter for Common Disease Genomics (CCDG) Neuropsychiatric: Autism Genetic Resource Exchange (AGRE)
Center for Common Disease Genomics (CCDG) Neuropsychiatric: Autism Genetic Resource Exchange (AGRE)
PRJNA513145 | ENA
GenomicsCenter for Common Disease Genomics (CCDG) Neuropsychiatric: Autism Genetic Resource Exchange (AGRE)
Center for Common Disease Genomics (CCDG) Neuropsychiatric: Autism Genetic Resource Exchange (AGRE)
PRJNA513146 | ENA
GenomicsLeishmania major
Origins of genetic exchange in Leishmania parasites
PRJNA788482 | ENA
GenomicsNatural genetic variation perturbs collaborative transcription factor binding required for enhancer selection and function
Natural genetic variation between two mouse strains was used as a natural mutagenesis screen to test various aspects of the proposed model for enhancer selection and function. Chromatin marks H3K4me2, H3K27Ac, and transcription factors PU.1, C/EBPa, and p65 were assessed by ChIP-Seq and GRO-Seq and ...
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-46494 | biostudies-arrayexpress
TranscriptomicsThe Rho Exchange Factors Vav2 and Vav3 Control a Lung MetastasisM-bM-^@M-^SSpecific Transcriptional Program in Breast Cancer Cells
The guanosine triphosphatases of the Rho and Rac subfamilies regulate protumorigenic pathways and are activated by guanine nucleotide exchange factors (Rho GEFs), which could be potential targets for anticancer therapies. We report that two Rho GEFs, Vav2 and Vav3, play synergistic roles in breast c...
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-33348 | biostudies-arrayexpress
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