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ProteomicsSpatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis
Lipids play a crucial role in signalling and metabolism, regulating the development and maintenance of the skeleton. Membrane lipids have been hypothesised to act as intermediates upstream of orphan phosphatase 1 (PHOSPHO1), a major contributor to phosphate generation required for bone mineralisatio...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-19 | PXD038909 | Pride
Mouse Maldi-ims Phospho1 Matrix mineralisation Disorders of calcium or phosphate metabolism Lipids Knee joint Growth plate Bone modelling and remodelling 
TranscriptomicsGene expression profiling of primary human bone marrow mesenchymal stromal cells (MSCs) cultured as 2D monolayers and 3D cellular aggregates (spheroids)
Human bone marrow mesenchymal stromal cells (MSCs) are conventionally cultured as adherent monolayers on tissue culture plastic. MSCs can also be cultured as 3D cell aggregates (spheroids). Optimised 3D conditions (60,000 MSCs cultured as a spheroid for 5 days) inhibited MSC proliferation and induce...
ORGANISM(S): Homo sapiens 
2015-09-30 | E-MTAB-3795 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of primary human bone marrow stromal cells (BMSCs) and telomerase-immortalised single cell derived clonal BMSC lines
Bone marrow stromal cells (BMSCs) provide hematopoietic support, immunoregulation and contain a stem cell fraction capable of skeletogenic differentiation. A heterogeneous population of primary bone marrow BMSCs were isolated from a single human donor (FH181), and a lentiviral expression system was ...
ORGANISM(S): Homo sapiens 
2015-07-23 | E-MTAB-3511 | biostudies-arrayexpress
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