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ProteomicsEnhancement of Tryptic Peptide Signals from Tissue Sections using MALDI IMS Post-ionization (MALDI-2)
Matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) allows for highly multiplexed, unlabeled mapping of analytes from tissue sections. However, further work is needed to improve sensitivity and depth of coverage for protein and peptide IMS. Laser-based post-ionization ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-30 | PXD023877 | Pride
Kidney Imaging mass spectrometry Maldi-2 Lc-ms/ms 
ProteomicsMALDI IMS Euterpe oleracea seed
MALDI-IMS of Euterpe oleracea (acai) seed: The spectra were acquired in positive mode, with 75-um lateral resolution and 200,000 mass resolution from 150 to 3000 Da in a Solarix XR FT-ICR 7T (Bruker Daltonics, Germany). The experiment data were analyzed by the SCiLS Lab MVS Version 2019c Premium 3D ...
ORGANISM(S): Euterpe Oleracea (ncbitaxon:115466) 
MSV000090325 | MassIVE
UnknownMultiplex enzyme activity imaging by MALDI-IMS of substrate library conversions.
Not available
S-EPMC7511933 | biostudies-literature
ProteomicsMALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility
Spermatogenesis is a complex multi-step process involving intricate interactions between different cell types in the male testis. Disruption of these interactions results in infertility. Combination of shotgun tissue proteomics with MALDI imaging mass spectrometry is markedly potent in revealing top...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-07 | PXD022870 | Pride
Maldi imaging mass spectrometry Mouse Estrogen Arom+ Male infertility Testis 
UnknownMonitoring the inflammatory response to infection through the integration of MALDI IMS and MRI.
Not available
S-EPMC3377982 | biostudies-literature
UnknownRelationship between MALDI IMS intensity and measured quantity of selected phospholipids in rat brain sections.
Not available
S-EPMC3025046 | biostudies-literature
ProteomicsSpatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis
Lipids play a crucial role in signalling and metabolism, regulating the development and maintenance of the skeleton. Membrane lipids have been hypothesised to act as intermediates upstream of orphan phosphatase 1 (PHOSPHO1), a major contributor to phosphate generation required for bone mineralisatio...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-19 | PXD038909 | Pride
Mouse Maldi-ims Phospho1 Matrix mineralisation Disorders of calcium or phosphate metabolism Lipids Knee joint Growth plate Bone modelling and remodelling 
UnknownDelineation of disease phenotypes associated with esophageal adenocarcinoma by MALDI-IMS-MS analysis of serum N-linked glycans.
Not available
S-EPMC5675076 | biostudies-literature
ProteomicsProtein profiling and identification of new biomarkers of brain ischemia by MALDI-imaging-mass-spectrometry
Introduction The identification of proteins involved in brain ischemia might allow the discovery of new putative biomarkers or potential therapeutic target of one of the most important neurological disorders. MALDI Imaging-Mass-Spectrometry (IMS) is a powerful technique that allows the visualization...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-14 | PXD003644 | Pride
Tmcao Biomarkers Brain ischemia Maldi imaging 
ProteomicsAlterations in lipid profile of the aging kidney identified by MALDI imaging mass spectrometry
During aging, the kidney undergoes functional and physiological changes that are closely affiliated with chronic kidney disease (CKD). There is increasing evidence supporting the role of lipid or lipid-derived mediators in the pathogenesis of CKD and other aging-related diseases. To understand the r...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-10 | PXD013860 | Pride
Ckd Lipidomics Chronic kidney disease Ims Renal fibrosis 
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