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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
ProteomicsSpatial lipidomic profiling of mouse joint tissue demonstrates the essential role of PHOSPHO1 in growth plate homeostasis
Lipids play a crucial role in signalling and metabolism, regulating the development and maintenance of the skeleton. Membrane lipids have been hypothesised to act as intermediates upstream of orphan phosphatase 1 (PHOSPHO1), a major contributor to phosphate generation required for bone mineralisatio...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-19 | PXD038909 | Pride
Mouse Maldi-ims Phospho1 Matrix mineralisation Disorders of calcium or phosphate metabolism Lipids Knee joint Growth plate Bone modelling and remodelling 
GenomicsRNA sequencing of wildtype and PHOSPHO1 knockout brown fat
RNA sequencing of wildtype and PHOSPHO1 knockout brown fat
PRJNA529783 | ENA
UnknownCompounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.
Not available
S-EPMC3711567 | biostudies-literature
UnknownRole of PHOSPHO1 in Periodontal Development and Function.
Not available
S-EPMC4914864 | biostudies-literature
UnknownSkeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.
Not available
S-EPMC4891278 | biostudies-literature
TranscriptomicsRNA sequencing of wildtype and PHOSPHO1 knockout brown fat
We report the RNA expression of the mature brown fat from 6 week old wild type (WT) and PHOSPHO1 knockout (KO) mice. Mature brown fat was isolated from brown adipose tissue after collagenase digestion. Increased expression of mitochondrial genes is found in KO brown fat.
ORGANISM(S): Mus musculus 
2020-07-08 | GSE129020 | GEO
UnknownPhosphocholine accumulation and PHOSPHO1 depletion promote adipose tissue thermogenesis.
Not available
S-EPMC7334538 | biostudies-literature
UnknownAblation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.
Not available
S-EPMC5247257 | biostudies-literature
UnknownPHOSPHO1 is a skeletal regulator of insulin resistance and obesity.
Not available
S-EPMC7584094 | biostudies-literature
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