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TranscriptomicsNascent-seq indicates widespread cotranscriptional RNA editing in Drosophila
The RNA editing enzyme ADAR chemically modifies adenosine (A) to inosine (I), which is interpreted by the ribosome as a guanosine. Here we assess cotranscriptional A-to-I editing in Drosophila, by isolating nascent RNA from adult fly heads and subjecting samples to high-throughput sequencing. There ...
ORGANISM(S): Drosophila melanogaster 
2012-05-31 | E-GEOD-37232 | biostudies-arrayexpress
TranscriptomicsADAR1-mediated A-to-I RNA editing is essential for erythropoiesis [RNA-seq]
Purpose: RNA editing by ADAR1 is essential for hematopoietic development. The goals of this study were firstly, to identify ADAR1-specific RNA-editing sites by indentifying A-to-I (G) RNA editing sites in wild type mice that were not edited or reduced in editing frequency in ADAR1 deficient murine e...
ORGANISM(S): Mus musculus 
2016-07-24 | E-GEOD-71042 | biostudies-arrayexpress
MetabolomicsNutritional quality and genetic differences of five amaranth cultivars revealed by metabolome profiling and whole-genome sequencing (Leaf assays)

BACKGROUND: Amaranth (Amaranthus spp.) has high nutritional quality, with edible grain and leaves, and many agronomic advantages, making it a promising part of the solution for global food insecurity. However, we lack comprehensive metabolomic and genome sequence data fo...

2025-02-25 | MTBLS3498 | MetaboLights
MetabolomicsNutritional quality and genetic differences of five amaranth cultivars revealed by metabolome profiling and whole-genome sequencing (Seed assays)

BACKGROUND: Amaranth (Amaranthus spp.) has high nutritional quality, with edible grain and leaves, and many agronomic advantages, making it a promising part of the solution for global food insecurity. However, we lack comprehensive metabolomic and genome sequence data fo...

2025-02-25 | MTBLS815 | MetaboLights
MetabolomicsWhole genome CRISPRi screening identifies druggable vulnerabilities in drug-resistant Mycobacterium tuberculosis

Tuberculosis (TB) remains a global health threat, aggravated by the emergence of drug-resistant strains. This study aims to identify genes and metabolic pathways with increased vulnerability in drug-resistant Mycobacterium tuberculosis strains compared to their drug-susceptible counterparts. Usin...

2024-10-15 | MTBLS11277 | MetaboLights
TranscriptomicsEvolutionary and ontogenetic changes in RNA editing in human, chimpanzee and macaque brains
we used RNA-Seq to quantify the RNA editing level at more than 8,000 previously annotated exonic A-to-I RNA editing sites in two brain regions - prefrontal cortex and cerebellum - of humans, chimpanzees and rhesus macaques. We observed substantial conservation of RNA editing levels between the brain...
ORGANISM(S): Macaca mulatta 
2014-01-07 | E-GEOD-45244 | biostudies-arrayexpress
TranscriptomicsThe dsRBP and inactive editor, ADR-1, utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome
Purpose: The purpose of this experiment is to expand the repertoire of C. elegans edited transcripts and identify the roles of ADR-1 as indirect regulator of editing and ADR-2 as the only active deaminase in vivo. Methods: Strand-specific RNA sequencing of wild-type and adr mutant worms, followed by...
ORGANISM(S): Caenorhabditis elegans 
2014-01-20 | E-GEOD-51556 | biostudies-arrayexpress
TranscriptomicsWhole-genome sequencing of Saccharomyces cerevisiae CEN.PK2-1C subjected to mtDNA base editing or Mito-BE screen
To identify mutations that occurred in the nuclear and mitochondrial DNA of the yeast subjected to mtDNA base editing or Mito-BE screen, we performed whole-genome sequencing of cultured yeast cells after isolation of mitochondrial DNA.
ORGANISM(S): Saccharomyces cerevisiae 
2024-11-01 | E-MTAB-13701 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification and functional analysis of Apobec-1 mediated C-to-U RNA editing in mouse small intestine and liver
The genome-wide identification, tissue-specificity and functional implications of Apobec-1 mediated C-to-U RNA editing remains incomplete. Deep sequencing, data filtering and validation from wild-type and Apobec-1 deficient mice revealed 56 novel editing sites in 54 intestinal mRNAs and 22 novel sit...
ORGANISM(S): Mus musculus 
2014-05-23 | E-GEOD-57910 | biostudies-arrayexpress
UnknownGenome editing in rice mediated by miniature size Cas nuclease SpCas12f.
Not available
S-EPMC10040665 | biostudies-literature
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