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TranscriptomicsIn vivo screen of Francisella tularensis subsp. novicida mutants in sequence defined transposon library
We used an inhalation mouse model of infection to query a collection of 2149 mutants in a Francisella tularensis subsp. novicida background for genes required for growth, survival and systemic dissemination. A microarray-based genome-wide negative selection screen (Microarray tracking of transposon ...
ORGANISM(S): Francisella tularensis subsp. novicida 
2008-12-30 | E-GEOD-11297 | biostudies-arrayexpress
TranscriptomicsA genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers
In a genome-wide screen of human cancer cell lines, we identified homozygous intragenic microdeletions involving genes encoding components of the apical-basal cell polarity complexes. Among these, PARD3 is disrupted in cell lines and primary tumors from squamous carcinomas and glioblastomas. Reco...
ORGANISM(S): Homo sapiens 
2011-11-03 | E-GEOD-20306 | biostudies-arrayexpress
TranscriptomicsGenome-wide cheater screen reveals safeguards for cell cooperation during embryogenesis
Ensuring cooperation among formerly autonomous cells has been a central challenge in the evolution of multicellular organisms. One solution is monoclonality, but this option does not eliminate genetic and epigenetic variability, leaving room for exploitative behavior. We therefore hypothesized that ...
ORGANISM(S): Mus musculus 
2013-10-21 | E-GEOD-49814 | biostudies-arrayexpress
GenomicsSystematic identification of G-quadruplex sensitive lethality by genome-wide genetic screening
A375 and HT1080 cells are treated with G-quadruplex ligands PDS or PhenDC3 following genome-wide shRNA knockdown. This enables the identification of genes that when silenced, specifically compromises cell growth in the presence of the ligand. First, a pilot screen was performed to determine a ligand...
ORGANISM(S): Homo sapiens 
2019-06-22 | E-MTAB-6367 | biostudies-arrayexpress
TranscriptomicsA genome-wide genetic interaction screen reveals metabolic roles of human histone deacetylase 1
Dynamic acetylation of metabolic proteins has emerged as a ubiquitous post-translational modification of human metabolic proteins. However, the corresponding modifying enzymes and the functions of the modification await exploration. Using a genome-wide synthetic lethality screen, we constructed a ge...
ORGANISM(S): Homo sapiens 
2012-02-10 | E-GEOD-29662 | biostudies-arrayexpress
GenomicsGenome-wide mapping of PRDM14 binding sites in human embryonic stem cells
PRDM14 belongs to the PR (PRDI-BF1 and RIZ) domain proteins (PRDM) family which is a subclass of the SET domain proteins, a common domain found in histone modifying enzymes. PRDM14 has been previously implicated to regulate self-renewal of hESCs as knock-down of PRDM14 induced expression of differen...
ORGANISM(S): Homo sapiens 
2010-10-20 | E-GEOD-22767 | biostudies-arrayexpress
GenomicsGenome-wide T. brucei RNAi screen with compound 25
Genome-wide T. brucei RNAi screen with compound 25
PRJEB38509 | ENA
ProteomicsA genome-wide screen for essentiality upon telomerase inhibition identifies a novel p53 regulator, C16ORF72/TAPR1
Telomere erosion contributes to age-associated tissue dysfunction and senescence, and p53 plays a crucial role in this response. We undertook a genome-wide screen to identify gene deletions that sensitized p53-positive human cells to loss of telomere integrity, and uncovered a previously unannotated...
ORGANISM(S): Homo sapiens (Human) 
2021-03-04 | PXD022128 | Pride
C16orf72 Crispr-cas9 Genome-wide screen Telomere erosion P53 Telomerase inhibitor 
GenomicsGenome-wide CRISPR KO screen in BMDMs [Bulk CIRSPR Screen]
Genome-wide CRISPR KO screen in BMDMs [Bulk CIRSPR Screen]
PRJNA865297 | ENA
GenomicsGenome-wide CRISPR-Cas9 screen (TKOv3) data on SUN2 degradation
Genome-wide CRISPR-Cas9 screen (TKOv3) data on SUN2 degradation
PRJEB54102 | ENA
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