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TranscriptomicsThe fine-scale and complex architecture of human copy number variation
Despite considerable excitement over the potential functional significance of copy number variants (CNVs), we still lack knowledge of the fine-scale architecture of the large majority of CNV regions in the human genome. In this study, we used a high-resolution array-based comparative genomic hybridi...
ORGANISM(S): Homo sapiens 
2008-01-23 | E-GEOD-9831 | biostudies-arrayexpress
ProteomicsIntegrative genomic and proteomic studies of Leishmania donovani strains revealed genetic features associated with drug resistance
Leishmaniasis is a neglected tropical disease affecting millions of people worldwide. Emerging drug resistance of Leishmania species poses threaten to the effective control and elimination of this neglected tropical disease. Here we conducted whole genome resequencing, proteome profiling, and compar...
ORGANISM(S): Leishmania <subgenus> 
2021-09-09 | PXD017089 | Pride
Genomic  proteomic  leishmania donovani  drug resistance 
ProteomicsLamin A acetylation shapes nuclear architecture and safeguards genomic integrity
The nuclear lamina constitutes more than a structural scaffold for the nucleus and plays a crucial role in protection of genomic integrity. Here we report that the loss of the lysine acetyl-transferase (KAT) MOF leads to nuclear architecture defects during interphase including micronuclei formation....
ORGANISM(S): Mus musculus (Mouse) 
2019-08-16 | PXD008539 | Pride
Acetylation Mouse Qexactive Lc-msms 
TranscriptomicsHigh resolution Hi-C analysis in S. pombe reveals fundamental elements of genome architecture [microarray CGH]
Eukaryotic genomes are folded into three-dimensional structures that govern diverse hromosomal procsses. Studeis in Drosophila and mammals have revealed large self-associating tomological domains whose borders are enriched in cohesin/CTCF factors that are required for long-range intrations. Howeve...
ORGANISM(S): Schizosaccharomyces pombe 
2014-10-22 | E-GEOD-56847 | biostudies-arrayexpress
GenomicsGenomic Architecture of LGL leukemia
Genomic Architecture of LGL leukemia
PRJNA702838 | ENA
GenomicsGenomic Architecture of LGL leukemia
Genomic Architecture of LGL leukemia
PRJNA702839 | ENA
TranscriptomicsThe Nucleosome Landscape of P. falciparum Reveals Chromatin Architecture and Dynamics of Regulatory Sequences
In eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-related processes. For P. falciparum, the causative agent of human malaria, the nucleosome landscape of the extremely AT-rich intergenic regulatory regions is largely unexplored. With the aid of a highly controlled MN...
ORGANISM(S): Plasmodium falciparum 
2015-11-25 | E-GEOD-66185 | biostudies-arrayexpress
GenomicsLoss of histone demethylase JARID1C triggers genomic instability in cancer.
Chromatin remodelers are recurrently mutated in cancer. Among these, JARID1C, (KDM5C) a histone demethylase, is frequently inactivated in clear cell renal cell carcinoma (ccRCC) patients. How the genetic inactivation of JARID1C leads to cancer remains largely unknown. Here we report that JARID1C bin...
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73267 | biostudies-arrayexpress
GenomicsIn vivo probing of the DNA-binding Architecture by bacterial arginine repressor
Although DNA motifs recognized by the transcription factors (TFs) have been determined, challenges remain in probing in vivo architecture of TF-DNA complexes on a genome-wide scale. Here, we show in vivo architecture of Escherichia coli arginine repressor (ArgR)-DNA complexes using chromatin immunop...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2015-04-01 | E-GEOD-60546 | biostudies-arrayexpress
GenomicsThe genomic architecture of mesothelioma
The genome-wide landscape of somatically acquired mutations in mesothelioma has not been deeply characterised to date, but advances in DNA sequencing technology now allow this to be addressed comprehensively. Harnessing massively parallel DNA sequencing platforms, we will identify somatically acquir...
EGAS00001000353 | EGA
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