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MetabolomicsAroma and quality of breads baked from old and modern wheat varieties and their prediction from genomic and flour-based metabolite profiles
Bread aroma is the principal characteristic perceived by the consumer yet it is mostly disregarded in the product chain. The main aim of this study was to evaluate the potential to include bread aroma as a new target criterion into the wheat product chain. The objectives of our study were to (i) qua...
2019-11-12 | MTBLS1187 | MetaboLights
MetabolomicsThe genomic and enzymatic basis for iridoid biosynthesis in cat thyme (Teucrium marum)
Iridoids are non-canonical monoterpenoids produced by both insects and plants. An example is the cat attracting and insect repelling volatile iridoid nepetalactone, produced by Nepeta sp. (catmint) and aphids. Recently, both nepetalactone biosynthetic pathways were elucidated, showing a remarkable c...
2026-04-20 | MTBLS9357 | MetaboLights
MetabolomicsNatural variation of root exudates in Arabidopsis thaliana-linking metabolomic and genomic data
The 19 parent lines of the Arabidopsis thaliana MAGIC collection show significant differences in their root exudate profiles. Changes in metabolism were analyzed by ultra-performance liquid chromatography coupled to electrospray ionization quadrupole time–of–flight mass spectrometry (UPLC-ESI-QTOF-M...
2017-02-03 | MTBLS160 | MetaboLights
MetabolomicsAn integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients

INTRODUCTION: The identification of frequent acquired mutations shows that patients with oligodendrogliomas have divergent biology with differing prognoses regardless of histological classification. A better understanding of molecular features as well as their metabolic pathways...

2021-10-06 | MTBLS869 | MetaboLights
MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
MetabolomicsChanges in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls
McDonald criteria and magnetic resonance imaging (MRI) are used for the diagnosis of multiple sclerosis (MS); nevertheless, it takes a considerable amount of time to make a clinical decision. Amino acid and fatty acid metabolic pathways are disturbed in MS, and this information could be useful for d...
2022-05-24 | MTBLS704 | MetaboLights
TranscriptomicsGenomic profiling of gastroesophageal adenocarcinoma
We aimed to characterize the genomic profiles of adenocarcinomas in the gastroesophageal junction in relation to cancers in the esophagus and the stomach. Profiles of gains/losses as well as gene expression profiles were obtained from 27 gastroesophageal adenocarcinomas using 32k high-resolution arr...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-22524 | biostudies-arrayexpress
MetabolomicsDistinct microbes, metabolites, and the host genome define the multi-omics profiles in right-sided and left-sided colon cancer

BACKGROUND: Studies have reported clinical heterogeneity between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). However, none of these studies used multi-omics analysis combining genetic regulation, microbiota and metabolites to explain the site-specific differ...

2024-12-16 | MTBLS10232 | MetaboLights
TranscriptomicsGenomic profiles of oxidative stress-induced rat renal cell carcinomas
Intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA) initiates Fenton reaction in the renal proximal tubules of rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatment. We performed high-resolution microarray comparative genomic hybridi...
ORGANISM(S): Rattus norvegicus 
2012-08-30 | E-GEOD-36101 | biostudies-arrayexpress
TranscriptomicsHigh-resolution comparative genomic hybridization of inflammatory breast cancer and identification of candidate genes
Inflammatory breast cancer (IBC) is an aggressive form of BC poorly defined at the molecular level. We compared the molecular portraits of 63 IBC and 134 non-IBC (nIBC) clinical samples. Genomic imbalances of 49 IBCs and 124 nIBCs were determined using high-resolution array-comparative genomic hybri...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-23720 | biostudies-arrayexpress
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