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TranscriptomicsComparative genomic hybridization of human breast tumor samples
Application of array comparative genomic hybridization (CGH) to the analysis of breast tumors
ORGANISM(S): Homo sapiens 
2006-11-27 | E-TABM-170 | biostudies-arrayexpress
GenomicsGenomic integrity safeguards pluripotency in embryonic stem cells
Genomic integrity safeguards pluripotency in embryonic stem cells
PRJNA438830 | ENA
GenomicsRole of Prdm14 in mouse embryonic stem cells: ChIP-seq and RNA-seq analyses
Prdm14 is a PR-domain and zinc-finger protein whose expression is restricted to the pluripotent cells of an early embryo, embryonic stem cells (ESCs), and germ cells. Here we show that Prdm14 safeguards mouse ESC maintenance by preventing induction of extraembryonic endoderm (ExEn) fates. Conversely...
ORGANISM(S): Mus musculus 
2010-12-23 | E-GEOD-25409 | biostudies-arrayexpress
UnknownBNIP3-dependent mitophagy safeguards ESC genomic integrity via preventing oxidative stress-induced DNA damage and protecting homologous recombination.
Not available
S-EPMC9675825 | biostudies-literature
ProteomicsPBRM1-deficient PBAF complexes target de novo genomic loci to activate pro-survival genes in clear cell renal cell carcinoma (PBRM1 dataset)
PBRM1 is lost in 40% of clear cell renal cell carcinomas (ccRCC) and the combined loss of VHL and PBRM1 drives ccRCC tumorigenesis. PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and despite its well-established role as a tumor suppressor, we have limited under...
ORGANISM(S): Homo Sapiens (human) 
PXD020554 | JPOST Repository
ProteomicsPBRM1-deficient PBAF complexes target de novo genomic loci to activate pro-survival genes in clear cell renal cell carcinoma (BRG1 dataset)
PBRM1 is lost in 40% of clear cell renal cell carcinomas (ccRCC) and the combined loss of VHL and PBRM1 drives ccRCC tumorigenesis. PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and despite its well-established role as a tumor suppressor, we have limited under...
ORGANISM(S): Homo Sapiens (human) 
PXD020553 | JPOST Repository
GenomicsThe totipotent 2C-like state safeguards genomic stability of mouse embryonic stem cells
The totipotent 2C-like state safeguards genomic stability of mouse embryonic stem cells
PRJNA1059497 | ENA
UnknownThe chromatin remodelling complex NoRC safeguards genome stability by heterochromatin formation at telomeres and centromeres.
Not available
S-EPMC3736129 | biostudies-literature
UnknownEpigenetic plasticity safeguards heterochromatin configuration in mammals.
Not available
S-EPMC10325917 | biostudies-literature
UnknownWnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells.
Not available
S-EPMC6353868 | biostudies-literature
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