Genotoxic stress

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Instrument Platform

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CHEBI ID

CHEBI:16027 (7)
CHEBI:15422 (6)
CHEBI:16919 (5)
CHEBI:15354 (5)
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CHEBI:15428 (4)
CHEBI:15891 (4)
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CHEBI:25017 (3)
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CHEBI:17154 (3)
CHEBI:17115 (3)
CHEBI:18123 (3)
CHEBI:16335 (3)
CHEBI:15940 (3)

Metabolite Name

UTP (3)
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GTP (2)
DTTP (2)
Crotamiton (2)
2-aminoadipic acid (2)
Leucine (2)
PC(16:0/16:0) (2)
Taurine (2)
Proline (2)
IMP (2)
Methionine (2)
Valine (2)
L-aspartic acid (2)
Putrescine (2)

IsPrivate

False (3)

First Public Date

2014 (54)
2025 (41)
2021 (38)
2026 (35)
2024 (31)
2023 (27)
2020 (20)
2017 (19)
2022 (17)
2019 (16)
2015 (14)
2013 (8)
2016 (7)
2018 (6)

Classification

bacteria (8)
fungi (5)

Modelling Approach

Ordinary differential equation model (3)

Modification

N6 (1)
N6-dimethyl-L-lysine (1)

Study type

Transcription profiling by array (661)
RNA-seq of coding RNA (98)
ChIP-seq (72)
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Other (13)
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Human - High-throughput sequencing (1)
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Bisulfite-seq (1)

Release Date

2015 (220)
2014 (211)
2013 (190)
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2012 (162)
2010 (161)
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2004 (11)
2002 (4)
2001 (2)
2000 (1)
1999 (1)
1997 (1)

Lab affiliation

MRC Toxicology Unit, University of Cambridge, UK (4)
Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (4)
Medical Oncology and Pulmonology, University Hospital Tübingen, Germany (3)
Department of Neuroscience of Disease, Brain Research Institute, Niigata University (2)
Biozentrum, University of Basel (1)
Core Unit Proteomics, Berlin Institute of Health at Charite - Universitaetsmedizin Berlin and Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany (1)
Department of Biochemistry and Molecular Biology, Faculty of Medical Sciences, Medical University of Lublin (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, U.S.A (1)
Department of Biology and Biotechnology ‘L. Spallanzani’, University of Pavia, via Ferrata 9, 27100, Pavia, Italy (1)
Department of Cancer Research and Molecular Medicine Faculty of Medicine Laboratory Centre, 5th floor. Erling Skjalgssons gt. 1 Norwegian University of Science and Technology NTNU 7006 Trondheim, Norway Tel: +47 72573076; Fax: +47 72576400 Cell. phone: +47 91825455 (1)
Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands (1)
Department of Chemistry and Chemical Biology, Barnett Institute of Chemical & Biological Analysis, Northeastern University, Boston, MA, United States (1)
Department of Experimental Oncology, IEO, European Institute of Oncology IRCCS, Milan 20139, Italy (1)
Department of Human Molecular Genetics and Biochemistry Tel Aviv University School of Medicine Tel Aviv 69987, Israel (1)
Department of Internal Medicine I, Center of IntegratedOncology, Cologne-Bonn Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne (1)
Department of Molecular Mechanisms of Disease, University of Zurich, CH-8057 Zurich, Switzerland (1)
Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland (1)
Department of Molecular Pharmacology and Therapeutics Columbia University Irving Medical Center (1)
Department of Proteomics and Signal Transduction Max Planck Institute of Biochemistry (1)
Department of human molecular genetics and biochemistry, Sackler faculty of medicine, Tel Aviv University, Israel. (1)
Division of Cellular and Systems Medicine, School of Medicine, University of Dundee, UK. DD1 9SY (1)
Erciyes University Genome and Stem Cell Center (GENKOK) (1)
Faculty of Biological Science University of Leeds UK (1)
Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases” (1)
First Faculty of Medicine, BIOCEV, Charles University in Prague, Czech Republic (1)
German Cancer Research Center (DKFZ), Heidelberg, Germany Medical Faculty, Heidelberg University, Heidelberg, Germany (1)
Head of Department Department of Molecular Mechanisms of Disease University of Zurich Winterthurerstr. 190 8057 Zurich, Switzerland (1)
Head of Proteomics Unit Spanish National Cancer Research Centre (CNIO) Melchor Fernández Almagro, 3. 28029 Madrid. SPAIN +34 917 328 000 Ext. 3110 (1)
Head of proteomics (1)
Helmholtz-Centre for Environmental Research - UFZ Department of Molecular Systems Biology Permoserstrasse 15 04318 Leipzig, Germany (1)

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CHIP Analysis - c-Jun/ATF2

Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress

ORGANISM(S): Homo sapiens

2010-06-05 | E-GEOD-1810 | biostudies-arrayexpress

Skin cancer-associated S. aureus downregulates DNA repair mechanisms, and promotes oxidative stress and DNA damage in human keratinocytes

Actinic keratoses (AK) are premalignant lesions common on photo-damaged skin that, over time, can progress to squamous cell carcinoma (SCC). A high bacterial load of Staphylococcus aureus is associated with AK and SCC but it is unknown whether this has a direct impact on skin cancer development. To ...

ORGANISM(S): Staphylococcus Capitis Staphylococcus Aureus Staphylococcus Epidermidis Staphylococcus

2022-05-17 | PXD031676 | panorama

Cotranscriptional exon skipping in the genotoxic stress response

Pre-mRNA splicing is functionally coupled to transcription, and genotoxic stresses can enhance alternative exon inclusion by affecting elongating RNA polymerase II. We report here that various genotoxic stress inducers, including camptothecin, inhibit the interaction between EWS, an RNA polymerase I...

ORGANISM(S): Homo sapiens

2010-06-09 | E-GEOD-21840 | biostudies-arrayexpress

BCL6 Enables Cancer Cells to Evade Genotoxic Stress

PRJNA679550 | ENA

Analysis of transcriptomic responses of genotoxic and non-genotoxic stress in human lymphoblastoid TK6 cells

PRJNA768817 | ENA

Transcription profiling of Arabidopsis response to genotoxic stress - AtGenExpress

AtGenExpress: A multinational coordinated effort to uncover the transcriptome of the multicellular model organism Arabidopsis thaliana. The activity of genes and their encoded products can be regulated in several ways, but transcription is the primary level, since all other modes of regulation (RNA ...

ORGANISM(S): Arabidopsis thaliana

2008-06-13 | E-GEOD-5625 | biostudies-arrayexpress

Taurine ameliorates oxidative stress of BMSCs and promotes osteogenesis in irradiated jaws

Osteoradionecrosis of the jaw (ORNJ) is a complication after head and neck radiotherapy that severely affects patients’ quality of life. Currently, an overall understanding of microenvironmental factors of ORNJ is still lacking. Here, we reveal the activation of taurine metabolism in irradiated mand...

2024-07-08 | MTBLS10284 | MetaboLights

Cardiac mtDNA and oxidative stress

Overexpression of twinkle protects cardiomyocytes from genotoxic stress caused by SOD2 heterozygocity

ORGANISM(S): Mus musculus

2013-11-01 | E-MEXP-3983 | biostudies-arrayexpress

The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress.

The Mycobacterium tuberculosis transcriptional landscape under genotoxic stress

PRJEB13114 | ENA

Konrath2023_genotoxic_stress_induced_IKK_NFkB_signaling

Ordinary differential equation-based model describing the genotoxic stress-induced activation of IKK/ NF-kB signaling.

2023-10-25 | MODEL2307130001 | BioModels