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TranscriptomicsIdentification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma
LMO2 regulates gene expression facilitating the formation of multipartite DNA-binding complexes. In B cells, LMO2 is specifically up-regulated in the Germinal Center (GC) reaction and is expressed in GC-derived non-Hodgkin’s lymphomas. LMO2 is one of the most powerful prognostic indicators in DLBCL ...
ORGANISM(S): Homo sapiens 
2012-07-12 | E-GEOD-34576 | biostudies-arrayexpress
TranscriptomicsExpression profiles of normal hematopoietic stem and progenitor cells and acute myeloid leukemia sub-populations
Acute Myeloid Leukemia AML is a cancer in which the process of normal cell hematopoietic differentiation is disrupted. Evidence exists that AML comprises a hierarchy with leukemic stem cells giving rise to more differentiated, but immature and functionally incompetent populations. The similarity of ...
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-63270 | biostudies-arrayexpress
TranscriptomicsMYC threshold required to maintain tumor phenotype
We demonstrate that there is a level of MYC expression that is required for maintaining a tumor phenotype and at this threshold there is a switch from a state of cellular proliferation to a state of proliferative arrest and apoptosis. We analyzed changes in gene expression by oligonucleotide microa...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-10200 | biostudies-arrayexpress
TranscriptomicsGene Expression Analysis Of Plasmablastic Lymphoma Identifies Down Regulation Of B Cell Receptor Signaling and Additional Unique Transcriptional Programs
Plasmablastic lymphoma is a high grade B cell lymphoma with plasmablastic morphology and a terminally differentiated B cell immunophenotype, usually arising in the setting of immunodeficiency and often demonstrating Epstein Barr Virus positivity. The molecular and genetic mechanisms underlying the ...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-GEOD-53117 | biostudies-arrayexpress
UnknownActive idiotypic vaccination versus control immunotherapy for follicular lymphoma.
Not available
S-EPMC4039868 | biostudies-literature
TranscriptomicsTargeting Unique Metabolic Properties of Breast Tumor Initiating Cells
Bulk cancer cell populations are known to display distinct metabolic properties compared to their normal counterparts. However, relatively little is known about heterogeneity of metabolic properties within tumors. In this study we show that, analogous to some normal stem cells, breast tumor initiati...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-41286 | biostudies-arrayexpress
TranscriptomicsEfficacy of bortezomib in a direct xenograft model of primary effusion lymphoma
Primary effusion lymphoma is an aggressive B-cell lymphoma most commonly diagnosed in HIV-positive patients and universally associated with Kaposi’s sarcoma-associated herpesvirus (KSHV). Chemotherapy treatment of PEL yields only short-term remissions in the vast majority of patients yet efforts to ...
ORGANISM(S): Mus musculus 
2010-07-20 | E-GEOD-22594 | biostudies-arrayexpress
TranscriptomicsLymphomas that recur after MYC suppression continue to exhibit oncogene addiction
The suppression of oncogenic levels of MYC is sufficient to induce sustained tumor regression associated with proliferative arrest, differentiation, cellular senescence and/or apoptosis, a phenomenon known as oncogene addiction. However, after prolonged inactivation of MYC in a conditional transgeni...
ORGANISM(S): Mus musculus 
2011-09-23 | E-GEOD-32341 | biostudies-arrayexpress
TranscriptomicsA Leukemic Stem Cell Expression Signature is Associated with Clinical Outcomes in Acute Myeloid Leukemia
Context: In many cancers, specific subpopulations of cells appear to be uniquely capable of initiating and maintaining tumors. The strongest support for this cancer stem cell model comes from transplantation assays in immune-deficient mice indicating that human acute myeloid leukemia (AML) is organi...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-24006 | biostudies-arrayexpress
GenomicsClonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the bone marrow that is the direct result of sequential acquisition of mutations in a single lineage of cells. In this study, we investigate a model in which this mutational acquisition occurs serially in long-lived self-renewing hemato...

phs000549.v1.p1 | EGA
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