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TranscriptomicsTranscription profiling of human leukemia cell lines treated with sera from Type I diabetes patients to investigate sera-induced transcriptional signatures.
Inflammation is common to many disorders and responsible for tissue and organ damage. However, the associated peripheral cytokine milieu is frequently dilute and difficult to measure, necessitating development of more sensitive and informative biomarkers for mechanistic studies, earlier diagnosis, a...
ORGANISM(S): Homo sapiens 
2010-09-16 | E-GEOD-24147 | biostudies-arrayexpress
TranscriptomicsMolecular signatures differentiate immune states in Type 1 Diabetes families
The complex milieu of inflammatory mediators associated with many diseases is often too dilute to directly measure in the periphery, necessitating development of more sensitive measurements suitable for mechanistic studies, earlier diagnosis, guiding selection of therapy, and monitoring intervention...
ORGANISM(S): Homo sapiens 
2014-05-13 | E-GEOD-52724 | biostudies-arrayexpress
TranscriptomicsThe temporal dynamics of proinflammatory and immuno-regulatory processes during progression to type 1 diabetes in the BioBreeding rat [rat]
A need exists for biomarkers in T1D that can 1) sensitively and specifically detect disease-related immune activity prior to, and independent of, measurement of auto-antibodies towards islet cell antigens; 2) define immunopathological mechanisms; and 3) monitor changes in the inflammatory state asso...
ORGANISM(S): Rattus norvegicus 
2013-06-01 | E-GEOD-40497 | biostudies-arrayexpress
TranscriptomicsThe temporal dynamics of proinflammatory and immuno-regulatory processes during progression to type 1 diabetes in the BioBreeding rat [human]
A need exists for biomarkers in T1D that can 1) sensitively and specifically detect disease-related immune activity prior to, and independent of, measurement of auto-antibodies towards islet cell antigens; 2) define immunopathological mechanisms; and 3) monitor changes in the inflammatory state asso...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-40496 | biostudies-arrayexpress
TranscriptomicsThe temporal dynamics of proinflammatory and immuno-regulatory processes during progression to type 1 diabetes in the BioBreeding rat
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2013-06-01 | E-GEOD-40498 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of pancreatic islets in BioBreeding rats
Like humans, the NOD mouse and other diabetes susceptible rat strains, T1D in BB rats is dependent on the major histocompatibility complex (MHC, insulin dependent diabetes mellitus locus 1, Iddm1) located on chromosome 20. In rats this is the HLA-DQB1 homologue RT1-B, specifically the RT1u haplotype...
ORGANISM(S): Rattus norvegicus 
2010-02-21 | E-GEOD-20214 | biostudies-arrayexpress
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