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TranscriptomicsGeoMX spatial transcriptomics of diffuse pleural mesothelioma: impact of CDKN2A deletion
We compared GeoMX spatially resolved gene expression profiles of diffuse pleural mesothelioma (DPM) samples with or without somatic CDKN2A deletion. 5 CDKN2Adel and 4 WT DPM samples were analyzed. A total of 202 Areas Of Illumination (AOIs) were transcriptionally profiled, of which 140 Sarcomatoid-...
ORGANISM(S): Homo sapiens 
2026-05-01 | E-MTAB-15378 | biostudies-arrayexpress
TranscriptomicsGeoMx digital spatial profiling on biopsies of triple negative breast cancer patients
In this study, we analyzed the differential spatial transcriptome of Triple-Negative Breast Cancer (TNBC) patients who responded in an opposite manner to neoadjuvant chemotherapy (NACT): we compared responders displaying pathological complete response (pCR) with no-responders who showed disease prog...
ORGANISM(S): Homo sapiens 
2023-10-12 | E-MTAB-13069 | biostudies-arrayexpress
TranscriptomicsGeoMX spatial transcriptomic on biphasic Malignant Pleural Mesothelioma
We applied a spatially resolved, high-dimensional transcriptomic approach to study MPM morpho-logical evolution. 139 regions across 8 biphasic MPMs (B-MPMs) were profiled using the GeoMx™Digital Spatial Profiler and Cancer Transcriptome Atlas to compare epithelioid and sarcomatoid components transcr...
ORGANISM(S): Homo sapiens 
2023-12-07 | E-MTAB-13043 | biostudies-arrayexpress
TranscriptomicsSpatially resolved transcriptomic profiling: an experimental comparison of GeoMx Digital Spatial Profiling and Visium CytAssist spatial transcriptomics in three cancer types (GeoMx)
We performed Visium CytAssist (10X), GeoMx DSP (Nanostring) and Chromium Flex (10X Genomics) full transcriptome profiling on Breast Cancer (BC), Lung Cancer (LC) and diffuse large B cell lymphoma (DLBCL) samples from archival FFPE blocks. We explore the data quality across blocks with different stor...
ORGANISM(S): Homo sapiens 
2024-11-01 | E-MTAB-14566 | biostudies-arrayexpress
TranscriptomicsGeoMx digital spatial profiling on enthesis biopsies from psoriatic arthritis patients before and after treatment with secukinumab
Enthesitis, a hallmark of psoriatic arthritis (PsA), reflects the interplay between mechanical stress and immune dysregulation at tendon-bone interfaces. We aimed to investigates the cellular and molecular responses in entheseal tissues following IL-17A inhibition in patients with active PsA. To ide...
ORGANISM(S): Homo sapiens 
2025-12-31 | E-MTAB-15134 | biostudies-arrayexpress
GenomicsGeoMx DSP- profiling of mouse spleen
GeoMx DSP- profiling of mouse spleen
PRJNA1152792 | ENA
UnknownstandR: spatial transcriptomic analysis for GeoMx DSP data.
Not available
S-EPMC10783521 | biostudies-literature
TranscriptomicsComparison of human induced pluripotent stem cell-derived intestinal tissue (xenografts) with normal adult human colon (NanoString GeoMX DSP)
Tissue samples from human induced pluripotent stem cell-derived intestinal tissue (iPSC-derived intestinal progenitors seeded onto collagen hydrogels) which were transplanted subcutaneously in mice. Mice were sacrificed and tissues were collected after 2, 3 or 4 weeks following engraftment. The tiss...
ORGANISM(S): Homo sapiens 
2025-02-05 | E-MTAB-13834 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomic analyses of triple negative and luminal A breast ductal carcinoma in situ
This experiment includes GeoMx spatial transcriptomic analyses of FFPE tissue from breast ductal carcinoma in situ lesions from 16 patients. All lesions were subject to ER, PR, HER2 and Ki67 immunohistochemistry and assigned a molecular subtype. The main aim was to compare DCIS of the two subtypes T...
ORGANISM(S): Homo sapiens 
2026-06-26 | E-MTAB-16918 | biostudies-arrayexpress
GenomicsGeoMX spatial transcriptomic on biphasic Malignant Pleural Mesothelioma
GeoMX spatial transcriptomic on biphasic Malignant Pleural Mesothelioma
PRJEB62875 | ENA
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