Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of human pediatric malignant germ cell tumors
To compare the transcriptome profiles of the two principal histological variants of malignant germ cell tumor that occur in childhood Experiment Overall Design: Here, we analyzed the global gene expression profiles of 27 pediatric MGCTs from the two principal histologies (18 yolk sac tumors [YSTs] a...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-10615 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult male germ cell tumours
Expression profiling of a panel of 101 adult male germ cell tumors and 5 normal testis specimens was performed on Affymetrix U133A and U133B microarrays. This data has been used to:; 1) generate a gene classifier that predicts histology (see PMID 15870693). 2) identify candidate target genes on 12p,...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3218 | biostudies-arrayexpress
TranscriptomicsGenotyping and analysis of chromosome copy number variation (CNV) from pediatric primary intracranial germ cell tumor
Intracranial pediatric germ cell tumors (GCTs) have different histological differentiations, prognosis and clinical behaviors. Prognosis of patients with germinoma and mature teratoma is good, while patients with other types of GCTs, termed as nongerminomatous malignant germ cell tumors (NGMGCTs), r...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19349 | biostudies-arrayexpress
ProteomicsProteomic profiling of CLDN6-deficient germ cell tumor cells
Representing a crucial factor during cell adhesion, polarity, proliferation and migration, the transmembrane protein claudin 6 (CLDN6) has been shown to be a putative target for the treatment of germ cell tumors (GCT). Particularly seminoma (SE), embryonal carcinoma (EC), and choriocarcinoma (CC) in...
ORGANISM(S): Homo sapiens (Human) 
2026-04-07 | PXD066158 | Pride
Germ cell tumor Seminoma Embryonal carcinoma Choriocarcinoma Yolk-sac tumor Cldn6 
GenomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (ChIP-seq data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56450 | biostudies-arrayexpress
TranscriptomicsTesticular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain
Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here, we report the identification of candidate disease genes...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-14354 | biostudies-arrayexpress
ProteomicsIdentification of factors secreted by testicular germ cell tumor cell lines and microenvironmental cells.
Type II germ cell tumors (GCTs) are the most common neoplasia in young men of age 14-45 years. It is generally accepted that GCTs arise from a common precursor lesion, called germ cell neoplasia in situ (GCNIS), eventually developing into seminomas or non-seminomas, such as (embryonal carcinomas, EC...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD031329 | Pride
Germ cell tumors Liquid chromatography coupled mass spectrometry Tumor microenvironment Secretome 
TranscriptomicsArray-based bioinformatic analysis on pediatric primary central nervous system germ cell tumors
This SuperSeries is composed of the following subset Series: GSE19347: microRNA expression data from pediatric primary intracranial germ cell tumor GSE19348: expression data from pediatric primary intracranial germ cell tumor GSE19349: Genotyping and analysis of chromosome copy number variation (CNV...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-19350 | biostudies-arrayexpress
GenomicMolecular Characterization of Germ Cell Tumors

We performed comprehensive molecular profiling of germ cell tumors, including whole exome sequencing and transcriptome sequencing, derived from patient samples. This project additionally explores mechanisms of chemosensivity in these patients, as well as mechanisms of tumor evolution in the conte...

phs000923 | dbGaP
GenomicsGenomic Screening of Testicular Germ Cell Tumors from Monozygotic Twins
Genomic screening was performed for one family containing MZ twins with testicular germ cell tumors, in order to define alterations associated with risk of tumor development. Copy number alterations were evaluated using array-CGH (4x44K, Agilent Technologies) in one seminoma and one embryonal carcin...
ORGANISM(S): Homo sapiens 
2015-01-31 | E-GEOD-62779 | biostudies-arrayexpress
Sort   by:  
 Page size