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UnknownSP-D Serum Levels Reveal Distinct Epithelial Damage in Direct Human ARDS.
Not available
S-EPMC7917979 | biostudies-literature
MetabolomicsCascading effects of root microbial symbiosis on the development and metabolome of the insect herbivore Manduca sexta L

Root mutualistic microbes can modulate the production of plant secondary metabolites affecting plant–herbivore interactions. Still, the main mechanisms underlying the impact of root mutualists on herbivore performance remain ambiguous. In particular, little is known about how changes in the plant...

2023-09-12 | MTBLS2700 | MetaboLights
ProteomicsImpact of exercise on the proteome of human peripheral blood mononuclear cells
This project aimed to characterize the impact of high-intensity interval exercise (HIIE) vs. moderate-intensity continuous exercise (MICE) on immune cell proteomics. In a randomized crossover study with 23 young, recreationally active runners, we isolated peripheral blood mononuclear cells (PBMCs) b...
ORGANISM(S): Homo sapiens (Human) 
2025-01-25 | PXD058573 | Pride
Exercise 
TranscriptomicsGenetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma
Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication stu...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8052 | biostudies-arrayexpress
ProteomicsHuman milk and gastric peptidomics
It is unclear to what degree protein degradation occurs in the infant stomach and whether peptides previously annotated for bioactivity are released. This study combined nanospray liquid chromatography separation with time of flight mass spectrometry, comprehensive structural libraries and informati...
ORGANISM(S): Homo sapiens (Human) 
2014-04-15 | PXD000688 | Pride
Peptidomics Human milk 
TranscriptomicsAtherosclerosis licenses for an exceeding immune response in COVID-19 disease by interferon priming in circulating myeloid cells
Single-cell RNA sequencing revealed a dysregulated myeloid immune response with hyperinflammatory and immunosuppressive features in patients with ASCVD and moderate COVID-19. Assay for Transposase-Accessible Chromatin sequencing and in-vitro experiments with isolated monocytes infected with SARS-CoV...
ORGANISM(S): Homo sapiens 
2025-01-15 | E-MTAB-16472 | biostudies-arrayexpress
ProteomicsPreterm birth increases endogenous human milk peptide release compared to term birth
Hundreds of naturally occurring milk peptides have been found in term human milk. Whether there are differences between the levels of these peptides between term and preterm milk remains unknown. Premature milk is produced before complete maturation of the mammary gland and is under the influence of...
ORGANISM(S): Homo sapiens (Human) 
2016-07-07 | PXD001079 | Pride
Peptidomics Human milk 
UnknownGenome-wide associations and functional gene analyses for endoparasite resistance in an endangered population of native German Black Pied cattle.
Not available
S-EPMC6454736 | biostudies-literature
ProteomicsiPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic/lysosomal dysfunction and impaired calcium homeostasis
Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal storage disorder Gaucher’s disease (GD), are the strongest genetic risk factor for Parkinson’s disease (PD) known to date. To elucidate the mechanisms underlying neurodegeneration in these patients, we generate...
ORGANISM(S): Homo sapiens (Human) 
2014-06-03 | PXD000866 | Pride
Tmt Neurons Human 
TranscriptomicsTranscription profiling of parthenocarpic tomato fruit
To evaluate the role of seeds in fruit quality, we induced parthenocarpy in tomato by regulating ovule-specific auxin synthesis or responsiveness using the INO promoter from A. thaliana, which is expressed in the outer layer of the integuments during early stages of ovule development. We compared th...
ORGANISM(S): Solanum lycopersicum 
2009-09-15 | E-GEOD-14358 | biostudies-arrayexpress
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