Sort   by:  
 Page size 
TranscriptomicsPI3 Kinase and FOXO1 activity differentially control B cells in the germinal center light and dark zone
PI3K signaling and FOXO transcription factors play opposing roles at several B cell developmental stages. We show here abundant nuclear FOXO1 expression in the proliferative compartment of the germinal center (GC), its dark zone (DZ), and PI3K activity, downregulating FOXO1, in the GC light zone (LZ...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-68043 | biostudies-arrayexpress
UnknownGerminal Center Kinases SmKIN3 and SmKIN24 Are Associated with the Sordaria macrospora Striatin-Interacting Phosphatase and Kinase (STRIPAK) Complex.
Not available
S-EPMC4587736 | biostudies-literature
ProteomicsRelocalizing transcriptional kinases to activate apoptosis_Proteomics Data
Kinases are critical regulators of cellular function that are commonly implicated in the mechanisms underlying disease. Most drugs that target kinases are molecules that inhibit their catalytic activity, but here we used chemically induced proximity to convert kinase inhibitors into activators of th...
ORGANISM(S): Homo sapiens (Human) 
2024-12-20 | PXD051502 | Pride
Cancer Lymphoma Transcription Kinase 
GenomicsEssential role of EBF1 in B cell immunity by controlling the generation and function of distinct mature B cell types
The transcription factor EBF1 is essential for lineage specification in early B cell development. Here we demonstrate by conditional mutagenesis that EBF1 was required for B cell commitment, pro-B cell development and subsequent transition to pre-B cells. Later in B cell development, EBF1 was essent...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-35857 | biostudies-arrayexpress
UnknownThe germinal center kinase GCK-1 is a negative regulator of MAP kinase activation and apoptosis in the C. elegans germline.
Not available
S-EPMC2757678 | biostudies-literature
GenomicsBorrowing Transcriptional Kinases to Activate Apoptosis [ChIP-seq]
Borrowing Transcriptional Kinases to Activate Apoptosis [ChIP-seq]
PRJNA1029047 | ENA
GenomicsBorrowing Transcriptional Kinases to Activate Apoptosis [RNA-seq]
Borrowing Transcriptional Kinases to Activate Apoptosis [RNA-seq]
PRJNA1029048 | ENA
GenomicsAn Interleukin 9-ZBTB18 axis promotes germinal center development of memory B cells
An Interleukin 9-ZBTB18 axis promotes germinal center development of memory B cells
PRJNA1215750 | ENA
ProteomicsTargeted quantification of phosphorylation sites in S. macrospora wildtype and STRIPAK-mutants
The composition of the striatin-interacting phosphatases and kinases (STRIPAK) signaling complex is highly similar in all eukaryotes and controls for the phosphorylation and dephosphorylation of target proteins. Associated with STRIPAK are germinal center kinases (GCK), some of which are part of con...
ORGANISM(S): Sordaria Macrospora 
2021-04-15 | PXD023130 | panorama
TranscriptomicsTranscription profiling of human lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis
The pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly due to the technical challenge of analyzing its rare neoplastic L&H cells, which are dispersed in an abundant non-neoplastic cellular microenvironme...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-12453 | biostudies-arrayexpress
Sort   by:  
 Page size