Transcription profiling of human lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis

ABSTRACT: The pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly due to the technical challenge of analyzing its rare neoplastic L&H cells, which are dispersed in an abundant non-neoplastic cellular microenvironment. We performed a genome-wide expression study of microdissected lymphocytic and histiocytic (L&H) lymphoma cells in comparison to normal and other malignant B cells, which indicates a relationship of L&H cells to and/or origin from germinal center B cells at transition to memory B cells. L&H cells show a surprisingly high similarity to the tumor cells of T cell-rich B cell lymphoma and classical Hodgkin lymphoma, a partial loss of their B cell phenotype and deregulation of many apoptosis-regul

ORGANISM(S): Homo sapiens

SUBMITTER: Ralf Küppers 

PROVIDER: E-GEOD-12453 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress