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The Epidermal Growth Factor Receptor (EGFR) has been studied extensively due to its critical role in cellular signaling and association with disease. Previous models have elucidated interactions between EGFR and downstream adaptor proteins, or showed phenotypes affected by EGFR. However, the link be...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-09 | PXD032403 | Pride
Targeted therapies for receptor tyrosine kinases are effective but invariably limited by drug resistance. In EGFR-mutant lung cancer, AXL activation drives resistance to erlotinib by restoring cell survival and migration. To map these signaling mechanisms, we generated a panel of lung adenocarcinoma...
ORGANISM(S): Homo sapiens (Human) 
2026-06-14 | PXD079076 | Pride
Next to genetic alterations, it is being recognized that the cellular environment also acts as a major determinant in onset and progression of disease. In cases where different cell types contribute to the final disease outcome, this imposes environmental challenges as different cell types likely di...
ORGANISM(S): Homo sapiens (Human) 
2023-02-06 | PXD029030 | Pride
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