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TranscriptomicsGene expression profiling in rat renal allografts after prolonged cold ischemia
Ischemia/reperfusion injury (IRI) has a major impact on the long-term outcome of renal allografts. However, the mechanisms of IRI related to chronic allograft nephropathy (CAN) are still poorly understood. To address this issue, in a F344 to Lewis transplantation model of the rat, kidneys were eithe...
ORGANISM(S): Rattus norvegicus 
2010-06-25 | E-GEOD-4441 | biostudies-arrayexpress
TranscriptomicsHigh weight differences between donor and recipient affect early kidney graft function -a role for IL-6 signaling
The frequency of delayed function of kidney transplants varies greatly and is associated with the quality of graft, donor age, and the duration of cold ischemia time. Body weight differences between donor and recipient can affect primary graft function. The underlying mechanism is poorly understood....
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-15813 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of presenilin deficient DP thymocytes
Notch1 signaling is an important regulator of cell fate in early stages of T cell development. Because Notch receptors can function redundantly, we sought an approach for inhibiting all endogenous Notch signaling in thymocytes. Upon ligand engagement, Notch receptors undergo two successive proteo...
ORGANISM(S): Mus musculus 
2007-09-14 | E-GEOD-6590 | biostudies-arrayexpress
TranscriptomicsInhibition of dendritic cell maturation and effector function
The initiation of donor derived dendritic cell (DC) adhesion and migration are one of the key events mediated by ischemia reperfusion injury (IRI) following solid organ transplantation. Recently we have been able to demonstrate that a single donor treatment with the synthetic metalloporphyrin cobalt...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-8452 | biostudies-arrayexpress
TranscriptomicsMechanisms and rescue strategies of Calcineurin inhibitor mediated tolerance abrogation
To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs IS. But IS such as calcineurin inhibitors CNI can interfere with tolerance induction. We investigated the effect of an additional CNI treatment on anti-CD4 mAb-induced tolerance induction upon rat ...
ORGANISM(S): Rattus norvegicus 
2013-09-01 | E-GEOD-40454 | biostudies-arrayexpress
TranscriptomicsE47 KO versus WT HSCs
Genome-wide gene expression pattern of E47 KO versus WT HSCs from primary and secondary recipient mice were analysis using Agilent one-color micro-array analysis. Two replicates from 4 samples are analyzed. The sample from the WT mouse were set as their reference sample.
ORGANISM(S): Mus musculus 
2011-01-22 | E-GEOD-26788 | biostudies-arrayexpress
TranscriptomicsIndices of Tolerance (IOT): Cross-platform biomarkers that identify kidney transplant tolerance
Being able to identify patients in whom immunological tolerance has been established or is developing would allow an individually tailored approach to post-transplant management of kidney allograft recipients. Ex vivo immunological monitoring was performed on samples from five groups of European ren...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-14655 | biostudies-arrayexpress
UnknownGene expression profiling of immunomagnetically separated cells directly from stabilized whole blood for multicenter clinical trials.
Not available
S-EPMC4424390 | biostudies-literature
UnknownDevelopment of a cross-platform biomarker signature to detect renal transplant tolerance in humans.
Not available
S-EPMC2877932 | biostudies-literature
UnknownSequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial.
Not available
S-EPMC5234822 | biostudies-literature
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