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GenomicsPolycomb preferentially targets stalled promoters of coding and non-coding transcripts
The Polycomb group (PcG) and Trithorax group (TrxG) of proteins are required for stable and heritable maintenance of repressed and active gene expression states. Their antagonistic function on gene control, repression for PcG and activity for TrxG, is mediated by binding to chromatin and subsequent ...
ORGANISM(S): Drosophila melanogaster 
2010-12-21 | E-GEOD-24521 | biostudies-arrayexpress
GenomicsGeneration of chromatin maps for ASH1 and FSH applying ChIP-seq
see Super Series Summary Cross-linked chromatin derived from Drosophila S2-DRSC cells was immunoprecipitated using antibodies targeting ASH1 and FSH. Precipitated chromatin was sequenced applying Illumina sequencing.
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-36404 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis klu-2 mutants vs. wild type
The Arabidopsis cytochrome P450 KLUH (KLU)/CYP78A5 promotes organ growth in a non-cell autonomous manner. To identify genes regulated by KLU activity, homozygous klu-2 mutants carrying constructs for EtOH-inducible overexpression of wild-type KLU (35S::AlcR-AlcA::KLU) or of enzymatically inactive KL...
ORGANISM(S): Arabidopsis thaliana 
2008-06-16 | E-GEOD-9201 | biostudies-arrayexpress
GenomicsThe BET protein FSH functionally interacts with ASH1 to orchestrate global gene activity in Drosophila
Background: The question of how cells re-establish gene expression states after cell division is still poorly understood. Genetic and molecular analyses have indicated that Trithorax group (TrxG) proteins are critical for the long-term maintenance of active gene expression states in many organisms. ...
ORGANISM(S): Drosophila melanogaster 
2013-02-06 | E-GEOD-36450 | biostudies-arrayexpress
TranscriptomicsGBM-Space: Joint Transcriptome and Chromatin Accessibility Profiling of Glioblastoma (10x Genomics - Multiome)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17183 | biostudies-arrayexpress
GenomicsEGAS00001000515-sc-20141203 - samples
This study aims to define the landscape of somatic mutations in sun exposed human skin by deep sequencing, analyse their frequency and use the data to infer the effect of mutations on proliferating cell behaviour. The frequency of each mutation will reflect the size of the clone of cells in the tiss...
EGAD00001001090 | EGA
GenomicsEGAS00001000603-sc-20140423 - samples
This study aims to define the landscape of somatic mutations in sun exposed human skin by deep sequencing, analyse their frequency and use the data to infer the effect of mutations on proliferating cell behaviour. The frequency of each mutation will reflect the size of the clone of cells in the tiss...
EGAD00001000825 | EGA
GenomicsEGAS00001000860-sc-20150105 - samples
Deep sequencing of two skin biopsies to study the landscape of somatic mutations in human adult tissues.
EGAD00001001123 | EGA
GenomicsUse of Deep Sequencing to Dectect Clonal Mutations In Sun Exposed Skin Epidermis PART2
This study aims to define the landscape of somatic mutations in sun exposed human skin by deep sequencing, analyse their frequency and use the data to infer the effect of mutations on proliferating cell behaviour. The frequency of each mutation will reflect the size of the clone of cells in the tiss...
EGAS00001000603 | EGA
GenomicsUse of deep sequencing to detect clonal mutations in sun exposed human epidermis whole genome
Deep sequencing of two skin biopsies to study the landscape of somatic mutations in human adult tissues.
EGAS00001000860 | EGA
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