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ProteomicsPlasma proteome profiling to detect and avoid sample-related biases in biomarker studies
Blood-based protein tests inform medical decision-making, but despite major investments, few new biomarkers reach the clinic. Plasma and serum are rich sources of information about an individual’s health state and mass spectrometry (MS)-based proteomics now allows highly specific and quantitative re...
ORGANISM(S): Homo sapiens (Human) 
2018-11-23 | PXD011749 | Pride
Plasma Quality Pre-analytics Biomarker Plasma proteome profiling 
ProteomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis o...
ORGANISM(S): Homo sapiens (Human) 
2019-03-04 | PXD011839 | Pride
Biomarker discovery/ mass spectrometry/ nafld/ nash/ plasma proteome profiling 
ProteomicsPlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specifi...
ORGANISM(S): Homo sapiens (Human) 
2018-12-07 | PXD009348 | Pride
Biomarker / diabetes / mass spectrometry / obesity / plasma proteome profiling / serum / gastric bypass surgery / global correlation profiles 
ProteomicsA novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics
To further integrate mass spectrometry (MS)-based proteomics into biomedical research and especially into clinical settings, high throughput and robustness are essential requirements. They are largely met in high-flow rate chromatographic systems for small molecules but these are not sufficiently se...
ORGANISM(S): Homo sapiens (Human) 
2018-08-16 | PXD010393 | Pride
Clinic Plasma Liquid chromatography 
ProteomicsRegion and cell-type resolved quantitative proteomic map of the human heart and its application to atrial fibrillation
The heart is a central human organ and its diseases are the leading cause of death worldwide, but an in-depth knowledge of the identity and quantity of its constituent proteins is still lacking. Here we determine the healthy human heart proteome by measuring 16 anatomical regions and three major car...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-03 | MSV000084410 | MassIVE
ProteomicsAccurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease
Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson’s disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Currently, there is no assay to qua...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD019814 | Pride
Phosphorylation stoichiometry Targeted mass spectrometry Parkinson’s disease 
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084333 | MassIVE
ProteomicsAccurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease
Pathogenic mutations in the Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson’s disease (PD). They increase its activity, resulting in augmented Rab10-Thr73 phosphorylation and conversely, LRRK2 inhibition decreases pRab10 levels. Monitoring pRab10 can thus serve as...
ORGANISM(S): Homo sapiens (Human) 
2020-07-03 | PXD015219 | Pride
Parkinson's disease Phosphoproteomics 
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins, its diseases should affect the plasma proteome. Plasma Proteome Profiling of 48 patients with cirrhosis ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084332 | MassIVE
ProteomicsUrinary proteome profiling in rats and humans unveils biomarkers of LRRK2 kinase activity in Parkinson's disease
Pathogenic mutations in Leucine-rich repeat kinase 2 (LRRK2) are the predominant genetic cause of Parkinson's disease (PD) and often lead to increased kinase activity, making LRRK2 inhibitors promising treatment options. However, despite ongoing clinical trials, specific, sensitive, and non-invasive...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-01-21 | PXD057308 | Pride
Urine Parkinson's disease Proteomics 
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