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UnknownDiscovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer.
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S-EPMC9415638 | biostudies-literature
ProteomicsDistinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis
Single-cell studies have revealed that intestinal macrophages maintain gut homeostasis through the balanced actions of reactive (inflammatory) and tolerant (non-inflammatory) subpopulations. How such balance is impaired in inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerat...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-23 | PXD066180 | Pride
Proteomics Gut homeostasis Tmt10 Bacterial sensing 
ProteomicsEvolution of Modularity, Interactome and Functions of GIV/Girdin (CCDC88A) from Invertebrates to Vertebrates
PDZ domains are one of the most abundant protein domains in eukaryotes and frequently found on junction-localized scaffold proteins. Various signaling molecules bind to PDZ proteins via PDZ-binding motifs (PBM) and finetune cellular signaling. Here we describe the presence of a PBM on GIV/Girdin (CC...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022601 | Pride
Lc-msms Cancer Human 
ProteomicsGrowth Signaling Autonomy in Circulating Tumor Cells Aids Metastatic Seeding
Self-sufficiency (autonomy) in growth signaling, the earliest recognized hallmark of cancer, is fuelled by the tumor cell’s ability to ‘secrete-and-sense’ growth factors; this translates into cell survival and proliferation that is self-sustained by auto-/paracrine secretion. Using breast cancer cel...
ORGANISM(S): Homo sapiens (Human) 
2023-02-06 | PXD037253 | Pride
Cancer Tmt Tumor Human 
ProteomicsA multi-omic analysis implicates the acquisition of CCDC88A/GIV through tumor-stroma tunnels in escape from tumor cell dormancy
Estrogen receptor-positive (ER+) breast cancer commonly disseminates to bone marrow, where interactions with mesenchymal stromal cells (MSCs) shape disease trajectory. Using a co-culture model, we performed an integrated transcriptomic and proteomic analysis of processes induced in ER+ breast cancer...
ORGANISM(S): Homo sapiens (Human) 
2024-07-02 | PXD039860 | Pride
Er+ Tmt Breast cancer Mesenchymal stromal cells 
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