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ProteomicsTMTpro: Design and initial evaluation of a novel Proline-based isobaric 16-plex Tandem Mass Tag reagent set
The design and synthesis of a novel proline-reporter-based isobaric Tandem Mass Tag 16 tag set (TMTpro) was carried out and the data uploaded here is a comparison of the performance of the new TMTpro tags with the current commercially available dimethylpiperidine-reporter-based TMT10/11 reagents. Da...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) Rattus norvegicus (Rat) 
2019-11-25 | PXD014750 | Pride
Tmt Tmtpro 
ProteomicsTMT10-TAILS investigation of the proteolytic landscape in B cell activation
The N-terminome in EBV-B cells from a human patient homozygous for an W580S mutation in MALT1 were analyzed by TMT10-plex TAILS and compared to EBV-B cells from heterozygous subjects under resting and PMA/ionomycin stimulation for 2 and 4 h.
ORGANISM(S): Homo sapiens (Human) 
2018-10-03 | PXD006723 | Pride
Human Malt1 B cell 
Proteomicshuman glioma cell-line proteomics upon treatment with different drugs
Increasing evidence suggests that induction of lethal autophagy carries potential significance for the treatment of glioblastoma (GBM). In continuation of our previous work, we investigated if autophagy-inducing compunds can trigger ATG-dependent cell death in human MZ-54 GBM cells and which pathway...
ORGANISM(S): Homo sapiens (Human) 
2021-02-26 | PXD015074 | Pride
Glioma Tmt10 Qexactive hf Human 
ProteomicsN-terminomics on WT and CASP2 KO mouse hearts
To identify putative substrates processed by Caspase-2 in response to PIDDosome activation in cardiomyocytes, we performed N-terminomics by TMT10-TAILS on P7 hearts isolated from XMLC2-Casp2fl/fl and XMLC2+Casp2fl/fl mice.
ORGANISM(S): Mus musculus (Mouse) 
2026-01-15 | PXD060421 | Pride
Tmt-tails Caspase 2 Heart developement N-terminomics 
ProteomicsProteomics of late signaling responses decipher the roles of Cbl and Cbl-b in neuroblastoma cell differentiation
We applied quantitative mass spectrometry (MS)-based proteomics to study the roles of Cbl and Cbl-b in long-term signaling responses related to neurite outgrowth and differentiation of SH-SY5Y neuroblastoma cells. Using stable isotope labeling by amino acids in cell culture (SILAC) and tandem mass t...
ORGANISM(S): Homo sapiens (Human) 
2021-03-30 | PXD020389 | Pride
Human Lc-msms Neuroblastoma Cbl Cblb 
ProteomicsTMT10-TAILS investigation of the proteolytic landscape in B cell activation
The N-terminome in EBV-B cells from a human patient homozygous for an W580S mutation in MALT1 were analyzed by TMT10-plex TAILS and compared to EBV-B cells from heterozygous subjects under resting and PMA/ionomycin stimulation for 2 and 4 h.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-10-11 | MSV000083027 | MassIVE
ProteomicsS. elongatus PCC 7942 Limited Proteolysis Structural Proteomics (JM-PB-DP3), TPP-MS-TMT10
The purpose of this experiment was to investigate structural alterations in proteins involved in central carbon metabolism and photosynthetic electron transfer pathways in Synechococcus elongatus PCC 7942. Sample data was obtained from S. elongatus PCC 7942 cell lysates treated across 10 temperature...
ORGANISM(S): Synechococcus Elongatus Pcc 7942 (ncbitaxon:1140) 
2025-07-29 | MSV000098679 | MassIVE
ProteomicsCharacterization of U937 cells after SAHA treatment
U937 cells were treated with SAHA and DMSO. Proteome and phosphoproteome were measured by TMT10 LC-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD063064 | Pride
Phosphoproteome Human Proteome 
ProteomicsCharacteristics of extracellular vesicles secreted by senescent human vascular smooth muscle cells and its influence on immune cells.
Atherosclerosis represents an age-related disease, which remains one of the leading cause of deaths in developed countries. It begins with a local deposition of lipid in the innermost part of the artery – intima. Thereafter a number of immune cells are attracted and infiltrate into the artery wall, ...
ORGANISM(S): Homo sapiens (Human) 
2022-09-08 | PXD030955 | Pride
Ev Vascular smooth muscle cells Human Extracellular vesicles Tmt10 Vsmcs 
ProteomicsTopical application of temperature sensitive gel containing caerin 1.1 and 1.9 peptides on TC-1 tumour bearing mice modulates heterogeneity of macrophage and dendritic cell in the tumour microenvironment
In this study, we demonstrate that, the topical application of a temperature-sensitive gel containing caerin 1.1 and 1.9 peptides significantly reduces the tumour weight of HPV 16 E6/E7 transformed TC-1 tumour bearing mice via improving the tumour microenvironment (TME) when compared with untreated ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025779 | Pride
Cervical cancer Tc-1 cell Cd8+ t cell Caerin peptide Tumour microenvironment 
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