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ProteomicsStable and temporal interactomes of CBL and CBLB
CBL family proteins have been widely reported as negative regulators of various signal pathways, which determines the amplitude and duration of signaling response through mediating the ubiquitination and degradation of activated receptors. CBL and CBLB share high degrees of structural similarities, ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-14 | PXD025250 | Pride
Cbl Cblb Signal transduction Dynamic protein complexes Ap-ms 
ProteomicsAnalysis of the CBL and CBLB signalosomes in primary T cells
T-cell receptor (TCR) signaling is essential for the function of T cells and negatively regulated by the E3 ubiquitin-protein ligases CBL and CBLB. Here we combine mouse genetics and affinity purification coupled to quantitative mass spectrometry to monitor the dynamics of the CBL and CBLB signaling...
ORGANISM(S): Mus musculus (Mouse) 
2016-12-14 | PXD004130 | Pride
Ap-ms Cblb Primary t cell Cbl Tcr Interactome Signalosome 
GenomicsGerminal Center B cells RNA-Seq (WT and Cbl-/-Cblb-/-)
Germinal Center B cells RNA-Seq (WT and Cbl-/-Cblb-/-)
PRJNA434305 | ENA
GenomicsDissecting the role of CBLB in human T cell activation and suppression
Dissecting the role of CBLB in human T cell activation and suppression
PRJNA816921 | ENA
GenomicsTumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells
Tumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells
PRJNA725425 | ENA
UnknownInhibition of CBLB protects from lethal Candida albicans sepsis.
Not available
S-EPMC6209141 | biostudies-literature
TranscriptomicsDissecting the role of CBLB in human T cell activation and suppression
Cbl-b is a negative regulator of T cell activation and in murine models a lack of CBLB results in resistance of T effectors to Tregs, a feature of T cells in many autoimmune diseases. Here, we used trackable gene-editing approaches to knock out CBLB in primary human CD4+ T cells. We found that CBLB-...
ORGANISM(S): Homo sapiens 
2022-07-19 | GSE198810 | GEO
UnknownTargeting CBLB as a potential therapeutic approach for disseminated candidiasis.
Not available
S-EPMC4975523 | biostudies-literature
TranscriptomicsGerminal Center B cells RNA-Seq (WT and Cbl-/-Cblb-/-)
We report the RNA transcriptome difference between WT and Cbl-/-Cblb-/- GC B cells
ORGANISM(S): Mus musculus 
2018-03-01 | GSE110698 | GEO
TranscriptomicsTumor rejection in Cblb-/- mice depends on IL-9 and Th9 cells
Casitas B lymphoma-b (Cbl-b) is a central negative regulator of cytotoxic T and NK cells, explaining its intracellular checkpoint function in cancer. Increasing evidence highlights the importance of CD4+ T helper cell populations (e.g., IL-9 producing T cells: Th9 cells) for anti-cancer immunity. We...
ORGANISM(S): Mus musculus 
2022-04-30 | GSE173395 | GEO
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